Oxidative Stress and Cardiometabolic Disorders

• Published in: BioMed research international Vol. 2021; pp. 9872109 - 3
• Main Authors: Akhigbe, Roland E., Ajayi, Ayodeji F., Ram, Sahu K.
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Acute phase proteins; Animal models; Animals; Antioxidants; Apoptosis; Blood circulation; Cardiac function; Cardiomyocytes; Cardiovascular Diseases - pathology; Care and treatment; Cerebral infarction; Congestive heart failure; Coronary artery; Diabetes; Diagnosis; Disease; Energy metabolism; Flavonoids; Glucose; Health aspects; Heart attack; Heart attacks; Heart failure; Heme; Humans; Hypertension; Hypoxia; Hypoxia-inducible factor 1a; Inflammation - pathology; Insulin resistance; Ischemia; Kinases; Lungs; Metabolic diseases; Metabolic Diseases - pathology; Metabolic disorders; Metabolic syndrome; Myocardial infarction; Oxidation; Oxidative stress; Oxidative Stress - physiology; Oxygenase; Pathophysiology; Phenols; Physiological aspects; Prevention; Proteins; Risk factors; Vascular endothelial growth factor; Nigeria
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2021/9872109

The authors clearly demonstrated that orosomucid 1, an acute-phase protein, attenuated inflammation and ischemic stroke in an animal model via upregulation of nuclear factor-like 2 (Nrf2) and suppression of heme oxygenase 1 (HO-1) [12]. The study in the fourth article “Qiliqiangxin Improves Cardiac Function through Regulating Energy Metabolism via HIF-1α-Dependent and Independent Mechanisms in Heart Failure Rats after Acute Myocardial Infarction,” authored by Y. Wang et al. was designed to evaluate the influence of Qiliqiangxin, QL, on energy metabolism in experimental myocardial infarction and the role of hypoxia-inducible factor 1α (HIF-1α) signaling [19]. Acute myocardial infarction (AMI) was established by ligating the left anterior descending coronary artery in adult male Sprague Dawley rats, and animals with an ejection fraction<50% at two weeks postoperation were considered animals with heart failure. Roland E. AkhigbeAyodeji F. AjayiSahu K. Ram [1] S. M. Grundy, J. I. Cleeman, S. R. Daniels, K. A. Donato, R. H. Eckel, B. A. Franklin, D. J. Gordon, R. M. Krauss, P. J. Savage, Smith SC Jr, J. A. Spertus, F. Costa, American Heart Association, National Heart, Lung, and Blood Institute, "Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement," Circulation, vol. 112 no. 17, pp. 2735-2752, DOI: 10.1161/CIRCULATIONAHA.105.169404, 2005.