Induced pluripotent stem cells as a model for diabetes investigation

Mouse and human induced pluripotent stem cells (iPSCs) may represent a novel approach for modeling diabetes. Taking this into consideration, the aim of this study was to generate and evaluate differentiation potential of iPSCs from lep db/db (db/db) mice, the model of diabetes type 2 as well as from...

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Bibliographic Details
Published in:	Scientific reports Vol. 5; no. 1; p. 8597
Main Authors:	Stepniewski, J., Kachamakova-Trojanowska, N., Ogrocki, D., Szopa, M., Matlok, M., Beilharz, M., Dyduch, G., Malecki, M. T., Jozkowicz, A., Dulak, J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26-02-2015 Nature Publishing Group
Subjects:	13/1 13/100 13/31 13/44 13/51 14/34 38 38/77 38/88 42 631/532/1360 631/532/2064/2158 Adult Alkaline phosphatase Angiogenesis Animals Biomarkers CD34 antigen Cell Differentiation Cells, Cultured Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - pathology Embryoid Bodies - metabolism Endothelial Progenitor Cells - metabolism Female Homeodomain Proteins - metabolism Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - metabolism Insulin Lewis X Antigen - metabolism Male Mice, Inbred C57BL Mice, Obese Middle Aged multidisciplinary Nanog Homeobox Protein Nuclear Proteins - metabolism Oct-4 protein Octamer Transcription Factor-3 - metabolism Pluripotency Rodents Science Stem cell transplantation Stem cells
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