A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain
Background In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each MCC population experiences vastly different local environments that may dictate differences in their lifetime and turnover rates. Ho...
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| Published in: | Developmental dynamics Vol. 249; no. 7; pp. 898 - 905 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Hoboken, USA
John Wiley & Sons, Inc
01-07-2020
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| Abstract | Background
In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each MCC population experiences vastly different local environments that may dictate differences in their lifetime and turnover rates. However, with the exception of MCCs in the trachea, the turnover rates of these multiciliated epithelial populations at extended time scales are not well described.
Results
Here, using genetic lineage‐labeling techniques we provide a direct comparison of turnover rates of MCCs in these three different tissues.
Conclusion
We find that oviduct turnover is similar to that in the airway (~6 months), while multiciliated ependymal cells turnover more slowly. |
|---|---|
| AbstractList | Background
In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each MCC population experiences vastly different local environments that may dictate differences in their lifetime and turnover rates. However, with the exception of MCCs in the trachea, the turnover rates of these multiciliated epithelial populations at extended time scales are not well described.
Results
Here, using genetic lineage‐labeling techniques we provide a direct comparison of turnover rates of MCCs in these three different tissues.
Conclusion
We find that oviduct turnover is similar to that in the airway (~6 months), while multiciliated ependymal cells turnover more slowly. In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each MCC population experiences vastly different local environments that may dictate differences in their lifetime and turnover rates. However, with the exception of MCCs in the trachea, the turnover rates of these multiciliated epithelial populations at extended time scales are not well described. Here, using genetic lineage-labeling techniques we provide a direct comparison of turnover rates of MCCs in these three different tissues. We find that oviduct turnover is similar to that in the airway (~6 months), while multiciliated ependymal cells turnover more slowly. BackgroundIn mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each MCC population experiences vastly different local environments that may dictate differences in their lifetime and turnover rates. However, with the exception of MCCs in the trachea, the turnover rates of these multiciliated epithelial populations at extended time scales are not well described.ResultsHere, using genetic lineage‐labeling techniques we provide a direct comparison of turnover rates of MCCs in these three different tissues.ConclusionWe find that oviduct turnover is similar to that in the airway (~6 months), while multiciliated ependymal cells turnover more slowly. Abstract Background In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each MCC population experiences vastly different local environments that may dictate differences in their lifetime and turnover rates. However, with the exception of MCCs in the trachea, the turnover rates of these multiciliated epithelial populations at extended time scales are not well described. Results Here, using genetic lineage‐labeling techniques we provide a direct comparison of turnover rates of MCCs in these three different tissues. Conclusion We find that oviduct turnover is similar to that in the airway (~6 months), while multiciliated ependymal cells turnover more slowly. |
| Author | Wallingford, John B. Konjikusic, Mia J. Gray, Ryan S. Tran, Ngan K. Fitch, Rebecca D. Roberson, Elle C. |
| AuthorAffiliation | 2 Department of Pediatrics, Dell Pediatric Research Institute, University of Texas at Austin, Austin, TX 78723 3 Department of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA 78712 1 Department of Molecular Biosciences, Patterson Labs, University of Texas at Austin, Austin, TX, USA 78712 |
| AuthorAffiliation_xml | – name: 2 Department of Pediatrics, Dell Pediatric Research Institute, University of Texas at Austin, Austin, TX 78723 – name: 1 Department of Molecular Biosciences, Patterson Labs, University of Texas at Austin, Austin, TX, USA 78712 – name: 3 Department of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA 78712 |
| Author_xml | – sequence: 1 givenname: Elle C. surname: Roberson fullname: Roberson, Elle C. organization: University of Texas at Austin – sequence: 2 givenname: Ngan K. surname: Tran fullname: Tran, Ngan K. organization: University of Texas at Austin – sequence: 3 givenname: Mia J. surname: Konjikusic fullname: Konjikusic, Mia J. organization: Dell Pediatric Research Institute, University of Texas at Austin – sequence: 4 givenname: Rebecca D. surname: Fitch fullname: Fitch, Rebecca D. organization: University of Texas at Austin – sequence: 5 givenname: Ryan S. surname: Gray fullname: Gray, Ryan S. organization: University of Texas at Austin – sequence: 6 givenname: John B. orcidid: 0000-0002-6280-8625 surname: Wallingford fullname: Wallingford, John B. email: wallingford@austin.utexas.edu organization: University of Texas at Austin |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32133718$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_dvdy_252 crossref_primary_10_1016_j_ceb_2022_102105 crossref_primary_10_1242_bio_059963 crossref_primary_10_1016_j_ydbio_2021_03_018 crossref_primary_10_1242_dmm_050137 crossref_primary_10_1083_jcb_202010034 crossref_primary_10_1038_s41419_024_06440_z crossref_primary_10_3390_jdb11010001 crossref_primary_10_1016_j_pharmthera_2021_107841 |
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In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the... In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each... Abstract Background In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the... BackgroundIn mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the... BACKGROUNDIn mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the... |
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| SubjectTerms | airway Brain cilia Comparative studies ependymal cell Ependymal cells Epithelium Fluid dynamics Fluid flow homeostasis mouse Oviduct Rodents Trachea |
| Title | A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain |
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