Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood–brain barrier

We investigated the expression and function of Abca1 in wild-type C57BL/6, abca1 (+/+), and abca1 (−/−) mice brain capillaries forming the blood–brain barrier (BBB). We first demonstrated by quantitative RT-PCR and Western immunoblot that Abca1 was expressed and enriched in the wild-type mouse brain...

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Bibliographic Details
Published in:	Molecular and cellular biochemistry Vol. 357; no. 1-2; pp. 397 - 404
Main Authors:	Do, Tuan Minh, Ouellet, Mélissa, Calon, Frédéric, Chimini, Giovanna, Chacun, Hélène, Farinotti, Robert, Bourasset, Fanchon
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-11-2011 Springer Springer Nature B.V
Subjects:	Analysis Animals ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Sub-Family G ATP-Binding Cassette Transporters - drug effects ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biochemistry Biomedical and Life Sciences Blood Blood-Brain Barrier - metabolism Brain Brain - metabolism Brain - surgery Cardiology Cholesterol Cholesterol - metabolism Life Sciences Medical Biochemistry Mice Mice, Inbred C57BL Mice, Transgenic Oncology Probucol - pharmacology Rodents Abca1 Abcb1 Mouse In situ brain perfusion Abcg4 Cholesterol Blood–brain barrier Abcg2
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