Acquired hypofibrinogenemia: current perspectives

• Published in: Journal of Blood Medicine Vol. 7; pp. 217 - 225
• Main Authors: Besser, Martin W, MacDonald, Stephen G
• Format: Journal Article Book Review
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2016; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Afibrinogenaemia; Antigens; Binding sites; Care and treatment; Chromosomes; Clauss Fibrinogen Assay; Coagulation protein disorders; Congenital diseases; Cryprecipitate; Direct Oral Anticoagulant (DOAC); Direct Thrombin Inhibitor (DTI); Dysfibrinogenaemia; FIBEM; Fibrinogen; Fibrinogen Antigen; Fibrinogen concentrate; Functional Fibringoen; Glycoproteins; Gravimetric Fibringoen Assay; Hemorrhage; Laboratories; Leukemia; Lupus; Patients; Plasma; Polymerization; Proteins; PT derived Fibringoen TEG; Review; ROTEM; Surgery; Thromboembolism; Thrombosis; Trauma; Viscoelastic materials; Viscoelastic Testing; United Kingdom > UK; afibrinogenemia; gravimetric fibrinogen assay; dysfibrinogenemia; fibrinogen antigen; viscoelastic testing; PT-derived fibrinogen; functional fibrinogen; Clauss fibrinogen assay; direct oral anticoagulant
• ISSN: 1179-2736; 1179-2736
• DOI: 10.2147/JBM.S90693

Acquired hypofibrinogenemia is most frequently caused by hemodilution and consumption of clotting factors. The aggressive replacement of fibrinogen has become one of the core principles of modern management of massive hemorrhage. The best method for determining the patient's fibrinogen level remains controversial, and particularly in acquired dysfibrinogenemia, could have major therapeutic implications depending on which quantification method is chosen. This review introduces the available laboratory and point-of-care methods and discusses the relative advantages and limitations. It also discusses current strategies for the correction of hypofibrinogenemia.