Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt

• Published in: International journal of molecular sciences Vol. 25; no. 5; p. 2652
• Main Authors: Salikhov, Shavkat I, Musin, Egor V, Kim, Aleksandr L, Oshchepkova, Yulia I, Tikhonenko, Sergey A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24-02-2024; MDPI
• Subjects: Acids; Aconitine - analogs & derivatives; Adsorption; allapinin; Anti-arrhythmia drugs; Antiarrhythmics; Arrhythmia; Capsules - chemistry; Cardiac arrhythmia; drug delivery; Drug dosages; encapsulation; Ethylenediaminetetraacetic acid; Glycyrrhizic Acid; polyelectrolyte microcapsules; Polyelectrolytes; Product introduction; prolonged release; Salt; Sodium Chloride; Sodium Chloride, Dietary; encapsulation; prolonged release; drug delivery; allapinin; polyelectrolyte microcapsules
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25052652

Allapinin has antiarrhythmic activity and can be used to prevent and treat various supraventricular and ventricular arrhythmias. Nevertheless, it is highly toxic and has a number of side effects associated with non-specific accumulation in various tissues. The complex of this substance with the monoammonium salt of glycyrrhizic acid (Al:MASGA) has less toxicity and improved antiarrhythmic activity. However, the encapsulation of Al:MASGA in polyelectrolyte microcapsules (PMC) for prolonged release will reduce the residual adverse effects of this drug. In this work, the possibility of encapsulating the allapinin-MASGA complex in polyelectrolyte microcapsules based on polyallylamine and polystyrene sulfonate was investigated. The encapsulation methods of the allapinin-MASGA in polyelectrolyte microcapsules by adsorption and coprecipitation were compared. It was found that the coprecipitation method did not result in the encapsulation of Al:MASGA. The sorption method facilitated the encapsulation of up to 80% of the original substance content in solution in PMC. The release of the encapsulated substance was further investigated, and it was shown that the release of the encapsulated Al:MASGA was independent of the substance content in the capsules, but at pH 5, a two-fold decrease in the rate of drug release was observed.