Role of TRPA1 and TRPV1 in the ROS-dependent sensory irritation of superior laryngeal capsaicin-sensitive afferents by cigarette smoke in anesthetized rats

Abstract Background Laryngeal exposure to cigarette smoke (CS) evokes sensory irritation, but the mechanisms are largely unclear. The TRPA1 and TRPV1 receptors are two types of Ca2+ -permeant channels located at the terminals of airway capsaicin-sensitive afferents. We investigated the mechanisms un...

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Bibliographic Details
Published in:	Pulmonary pharmacology & therapeutics Vol. 26; no. 3; pp. 364 - 372
Main Authors:	Liu, Bi-Yu, Tsai, Tung-Lung, Ho, Ching-Yin, Lu, Shing-Hwa, Lai, Ching Jung, Kou, Yu Ru
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2013
Subjects:	Acetanilides - pharmacology Acetylcysteine - pharmacology Animals Antioxidants - pharmacology Apnea - chemically induced Apnea - physiopathology Calcium Channels - metabolism Capsaicin - analogs & derivatives Capsaicin - pharmacology Chelating Agents - pharmacology Cigarette smoke Dose-Response Relationship, Drug Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Indomethacin - pharmacology Laryngeal capsaicin-sensitive afferents Laryngeal Nerves Laryngeal sensory irritation Larynx - drug effects Medical Education Neurons, Afferent - drug effects Pulmonary/Respiratory Purines - pharmacology Rats Reactive oxygen species Reactive Oxygen Species - pharmacology Smoking - physiopathology TRPA1 TRPA1 Cation Channel TRPC Cation Channels - drug effects TRPV Cation Channels - drug effects TRPV1 Reactive oxygen species transient receptor potential ankyrin 1 TRPA1 transient receptor potential vanilloid 1 AITC TRPV1 ethylene glycol-bis(β-aminoethyl ether)-N,N,N,N,-tetraacetic acid CPZ nordihydroguaiaretic acid Laryngeal capsaicin-sensitive afferents allyl isothiocyanate EGTA CS α,β-methylene-ATP NAC superior laryngeal nerves Laryngeal sensory irritation NDGA ROS capsazepine SLNs Cigarette smoke N-acetyl- l-cysteine α,β-meATP
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