Predisposing roles of paraoxonase-1 genetic variants in Korean ischemic stroke patients
Paraoxonase-1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. The aims of this study were to evaluate the role of PON1 gene polymorphisms (-107C[T, L55M, and Q192R) in patients susceptible to ischemic stroke...
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| Published in: | Genes & genomics Vol. 37; no. 7; pp. 579 - 586 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Seoul
The Genetics Society of Korea
01-07-2015
한국유전학회 |
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| Abstract | Paraoxonase-1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. The aims of this study were to evaluate the role of PON1 gene polymorphisms (-107C[T, L55M, and Q192R) in patients susceptible to ischemic stroke and to determine the interactive relationship between PON1 gene polymorphisms and vascular risk factors regarding stroke occurrence. The PON1 polymorphisms were not significantly different between 471 stroke patients and 427 control subjects. When stratified by the size of the occluded vessel, the PON1 L55M polymorphism was associated with patients with small-vessel disease (LM + MM; AOR, 2.161; 1.204 - 3.880). In gene - environment or gene - nutrient interaction analysis, significant interactions associated with increased stroke risk were found. Of those significantinteractions, the PON1 55LM + MM genotype with a plasma folate level 3.57 ng/ml accelerated the stroke prevalence 5.793-fold (AOR, 5.793; 95 % CI 1.575'21.306). Our study suggested that genetic associations of PON1 with ischemic stroke were affected by pathophysiological and environmental factors. Further studies are needed to elucidate the interactions of PON1 with other stroke risk factors in large populations. |
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| AbstractList | Paraoxonase-1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. The aims of this study were to evaluate the role of PON1 gene polymorphisms (-107C[T, L55M, and Q192R) in patients susceptible to ischemic stroke and to determine the interactive relationship between PON1 gene polymorphisms and vascular risk factors regarding stroke occurrence. The PON1 polymorphisms were not significantly different between 471 stroke patients and 427 control subjects. When stratified by the size of the occluded vessel, the PON1 L55M polymorphism was associated with patients with small-vessel disease (LM + MM; AOR, 2.161; 1.204 - 3.880). In gene - environment or gene - nutrient interaction analysis, significant interactions associated with increased stroke risk were found. Of those significantinteractions, the PON1 55LM + MM genotype with a plasma folate level 3.57 ng/ml accelerated the stroke prevalence 5.793-fold (AOR, 5.793; 95 % CI 1.575'21.306). Our study suggested that genetic associations of PON1 with ischemic stroke were affected by pathophysiological and environmental factors. Further studies are needed to elucidate the interactions of PON1 with other stroke risk factors in large populations. Paraoxonase-1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. The aims of this study were to evaluate the role of PON1 gene polymorphisms (-107C > T, L55M, and Q192R) in patients susceptible to ischemic stroke and to determine the interactive relationship between PON1 gene polymorphisms and vascular risk factors regarding stroke occurrence. The PON1 polymorphisms were not significantly different between 471 stroke patients and 427 control subjects. When stratified by the size of the occluded vessel, the PON1 L55M polymorphism was associated with patients with small-vessel disease (LM + MM; AOR, 2.161; 1.204-3.880). In gene-environment or gene-nutrient interaction analysis, significant interactions associated with increased stroke risk were found. Of those significant interactions, the PON1 55LM + MM genotype with a plasma folate level <3.57 ng/ml accelerated the stroke prevalence 5.793-fold (AOR, 5.793; 95 % CI 1.575-21.306). Our study suggested that genetic associations of PON1 with ischemic stroke were affected by pathophysiological and environmental factors. Further studies are needed to elucidate the interactions of PON1 with other stroke risk factors in large populations. Paraoxonase-1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. The aims of this study were to evaluate the role of PON1 gene polymorphisms (-107C[T, L55M, and Q192R) in patients susceptible to ischemic stroke and to determine the interactive relationship between PON1 gene polymorphisms and vascular risk factors regarding stroke occurrence. The PON1 polymorphisms were not significantly different between 471 stroke patients and 427 control subjects. When stratified by the size of the occluded vessel, the PON1 L55M polymorphism was associated with patients with small-vessel disease (LM ? MM; AOR, 2.161; 1.204–3.880). In gene–environment or gene–nutrient interaction analysis, significant interactions associated with increased stroke risk were found. Of those significant interactions, the PON1 55LM ? MM genotype with a plasma folate level \3.57 ng/ml accelerated the stroke prevalence 5.793-fold (AOR, 5.793; 95 % CI 1.575–21.306). Our study suggested that genetic associations of PON1 with ischemic stroke were affected by pathophysiological and environmental factors. Further studies are needed to elucidate the interactions of PON1 with other stroke risk factors in large populations. KCI Citation Count: 2 Paraoxonase-1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. The aims of this study were to evaluate the role of PON1 gene polymorphisms (−107C > T, L55M, and Q192R) in patients susceptible to ischemic stroke and to determine the interactive relationship between PON1 gene polymorphisms and vascular risk factors regarding stroke occurrence. The PON1 polymorphisms were not significantly different between 471 stroke patients and 427 control subjects. When stratified by the size of the occluded vessel, the PON1 L55M polymorphism was associated with patients with small-vessel disease (LM + MM; AOR, 2.161; 1.204–3.880). In gene–environment or gene–nutrient interaction analysis, significant interactions associated with increased stroke risk were found. Of those significant interactions, the PON1 55LM + MM genotype with a plasma folate level <3.57 ng/ml accelerated the stroke prevalence 5.793-fold (AOR, 5.793; 95 % CI 1.575–21.306). Our study suggested that genetic associations of PON1 with ischemic stroke were affected by pathophysiological and environmental factors. Further studies are needed to elucidate the interactions of PON1 with other stroke risk factors in large populations. Paraoxonase-1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. The aims of this study were to evaluate the role of PON1 gene polymorphisms (−107C > T, L55M, and Q192R) in patients susceptible to ischemic stroke and to determine the interactive relationship between PON1 gene polymorphisms and vascular risk factors regarding stroke occurrence. The PON1 polymorphisms were not significantly different between 471 stroke patients and 427 control subjects. When stratified by the size of the occluded vessel, the PON1 L55M polymorphism was associated with patients with small-vessel disease (LM + MM; AOR, 2.161; 1.204–3.880). In gene–environment or gene–nutrient interaction analysis, significant interactions associated with increased stroke risk were found. Of those significant interactions, the PON1 55LM + MM genotype with a plasma folate level <3.57 ng/ml accelerated the stroke prevalence 5.793-fold (AOR, 5.793; 95 % CI 1.575–21.306). Our study suggested that genetic associations of PON1 with ischemic stroke were affected by pathophysiological and environmental factors. Further studies are needed to elucidate the interactions of PON1 with other stroke risk factors in large populations. |
| Author | Jeon, Y.J., CHA University, Seongnam, Republic of Korea Cho, S.H., CHA University, Seongnam, Republic of Korea Kim, N.K., CHA University, Seongnam, Republic of Korea Kim, O.J., CHA University, Seongnam, Republic of Korea Kim, J.O., CHA University, Seongnam, Republic of Korea Choi, G.H., CHA University, Seongnam, Republic of Korea Shin, J.S., CHA University, Seongnam, Republic of Korea Han, I.B., CHA University, Seongnam, Republic of Korea Shin, B.S., Chonbuk National University Hospital, Jeonju, Republic of Korea Cho, Y., CHA University, Seoul, Republic of Korea Oh, S.H., CHA University, Seongnam, Republic of Korea |
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| CitedBy_id | crossref_primary_10_1016_j_clinbiochem_2017_08_001 crossref_primary_10_1038_s41598_017_12668_x crossref_primary_10_3389_fstro_2023_1274555 |
| Cites_doi | 10.1016/j.gene.2012.06.031 10.1111/ene.12074 10.1161/01.RES.0000146094.59640.13 10.1016/j.amepre.2006.08.019 10.1055/s-2007-1016288 10.1001/jama.288.16.2015 10.1016/0021-9150(93)90183-U 10.1016/S0021-9150(99)00340-8 10.3346/jkms.2009.24.4.561 10.1016/j.clinbiochem.2009.02.017 10.1002/humu.20522 10.1515/CCLM.2001.054 10.1021/bi00106a010 10.1161/01.STR.24.1.35 10.1196/annals.1367.008 10.1161/CIRCULATIONAHA.105.570846 10.1161/01.STR.0000016928.60995.BD 10.1093/aje/kwm395 10.1186/1471-2350-7-28 10.1111/j.1432-1033.1993.tb17620.x 10.1161/01.STR.0000185703.88944.7d |
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| Snippet | Paraoxonase-1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. The... Paraoxonase-1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. The... |
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| SubjectTerms | Animal Genetics and Genomics Biomedical and Life Sciences CARDIOVASCULAR DISEASES ENFERMEDADES CARDIOVASCULARES Human Genetics Life Sciences MALADIE CARDIOVASCULAIRE Microbial Genetics and Genomics Paraoxonase-1,Polymorphism,Risk factors,Gene - environment interaction Plant Genetics and Genomics Research Article 생물학 |
| Title | Predisposing roles of paraoxonase-1 genetic variants in Korean ischemic stroke patients |
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