Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60–5521, a potent inhibitor of cholesteryl ester transfer protein

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of cholesterol esters from the cardioprotective high density lipoprotein cholesterol (HDL‐C) to the proatherogenic low density lipoprotein cholesterol (LDL‐C) a...

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Bibliographic Details
Published in:	British journal of clinical pharmacology Vol. 73; no. 2; pp. 210 - 218
Main Authors:	Boettcher, Michael‐Friedrich, Heinig, Roland, Schmeck, Carsten, Kohlsdorfer, Christian, Ludwig, Matthias, Schaefer, Anja, Gelfert‐Peukert, Sabine, Wensing, Georg, Weber, Olaf
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-02-2012 Blackwell Blackwell Science Inc
Subjects:	Administration, Oral Adult Biological and medical sciences Blood Pressure - drug effects Cholesterol Ester Transfer Proteins - antagonists & inhibitors Cholesterol, HDL - blood cholesteryl ester transfer protein Clinical Trials concentration–effect relationship Dose-Response Relationship, Drug Dyslipidemias - drug therapy Dyslipidemias - metabolism Electrocardiography - drug effects first in man Heart Rate - drug effects Humans Hydroxyquinolines - adverse effects Hydroxyquinolines - pharmacokinetics Hydroxyquinolines - pharmacology Male Medical sciences Middle Aged pharmacodynamics pharmacokinetics Pharmacology. Drug treatments Single-Blind Method Young Adult Human Pharmacokinetic pharmacodynamic relationship Pharmacodynamics Toxicity cholesteryl ester transfer protein Single dose Male first in man Biological activity Protein Ester Activity concentration relation concentration-effect relationship Adult Inhibitor Safety Pharmacokinetics
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