Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease: Review and Meta-Analysis

Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease: Review and Meta-Analysis

Alzheimer's disease is the most common type of dementia, reaching 60-80% of case totals, and is one of the major global causes of the elderly population's decline in functionality concerning daily life activities. Epidemiological research has already indicated that, in addition to several...

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Published in:Biomedicines Vol. 10; no. 4; p. 778
Main Authors: Athanasaki, Athanasia, Melanis, Konstantinos, Tsantzali, Ioanna, Stefanou, Maria Ioanna, Ntymenou, Sofia, Paraskevas, Sotirios G, Kalamatianos, Theodosis, Boutati, Eleni, Lambadiari, Vaia, Voumvourakis, Konstantinos I, Stranjalis, George, Giannopoulos, Sotirios, Tsivgoulis, Georgios, Paraskevas, George P
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 27-03-2022
MDPI
Subjects:
Alzheimer's disease
Autophagy
Bias
Cognitive ability
common mechanisms
Dementia
Dementia disorders
Diabetes
Diabetes mellitus (non-insulin dependent)
Epidemiology
Genes
Glucose
Hyperglycemia
Inflammation
Insulin resistance
Meta-analysis
Metabolism
Mutation
Neurodegenerative diseases
Plasma
Proteins
Risk factors
Systematic Review
type 2 diabetes mellitus
Alzheimer’s disease
type 2 diabetes mellitus
common mechanisms
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Abstract Alzheimer's disease is the most common type of dementia, reaching 60-80% of case totals, and is one of the major global causes of the elderly population's decline in functionality concerning daily life activities. Epidemiological research has already indicated that, in addition to several others metabolic factors, diabetes mellitus type 2 is a risk factor of Alzheimer's disease. Many molecular pathways have been described, and at the same time, there are clues that suggest the connection between type 2 diabetes mellitus and Alzheimer's disease, through specific genes, autophagy, and even inflammatory pathways. A systematic review with meta-analysis was conducted, and its main goal was to reveal the multilevel connection between these diseases.
AbstractList Alzheimer’s disease is the most common type of dementia, reaching 60–80% of case totals, and is one of the major global causes of the elderly population’s decline in functionality concerning daily life activities. Epidemiological research has already indicated that, in addition to several others metabolic factors, diabetes mellitus type 2 is a risk factor of Alzheimer’s disease. Many molecular pathways have been described, and at the same time, there are clues that suggest the connection between type 2 diabetes mellitus and Alzheimer’s disease, through specific genes, autophagy, and even inflammatory pathways. A systematic review with meta-analysis was conducted, and its main goal was to reveal the multilevel connection between these diseases.
Author Tsantzali, Ioanna
Kalamatianos, Theodosis
Lambadiari, Vaia
Paraskevas, George P
Voumvourakis, Konstantinos I
Stranjalis, George
Melanis, Konstantinos
Paraskevas, Sotirios G
Giannopoulos, Sotirios
Boutati, Eleni
Ntymenou, Sofia
Stefanou, Maria Ioanna
Athanasaki, Athanasia
Tsivgoulis, Georgios
AuthorAffiliation 3 1st Department of Neurosurgery, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, Greece; tkalamatian@med.uoa.gr (T.K.); stranjal@otenet.gr (G.S.)
1 Department of Neurology, Evangelismos Hospital, 10676 Athens, Greece; athanasia.athan@yahoo.gr (A.A.); sofia_ntymenou@hotmail.com (S.N.)
4 2nd Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece; boutati@otenet.gr (E.B.); lambadiarihbc@gmail.com (V.L.)
2 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece; melaniskos@gmail.com (K.M.); docjo1989@gmail.com (I.T.); marianna421@hotmail.co.uk (M.I.S.); sotirispar5@gmail.com (S.G.P.); cvoumvou@otenet.gr (K.I.V.); ssgiannopoulos@gmail.com (S.G.); tsivgoulisgiorg@yahoo.gr (G.T.)
AuthorAffiliation_xml – name: 3 1st Department of Neurosurgery, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, Greece; tkalamatian@med.uoa.gr (T.K.); stranjal@otenet.gr (G.S.)
– name: 4 2nd Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece; boutati@otenet.gr (E.B.); lambadiarihbc@gmail.com (V.L.)
– name: 1 Department of Neurology, Evangelismos Hospital, 10676 Athens, Greece; athanasia.athan@yahoo.gr (A.A.); sofia_ntymenou@hotmail.com (S.N.)
– name: 2 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece; melaniskos@gmail.com (K.M.); docjo1989@gmail.com (I.T.); marianna421@hotmail.co.uk (M.I.S.); sotirispar5@gmail.com (S.G.P.); cvoumvou@otenet.gr (K.I.V.); ssgiannopoulos@gmail.com (S.G.); tsivgoulisgiorg@yahoo.gr (G.T.)
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  surname: Voumvourakis
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  orcidid: 0000-0002-2481-3060
  surname: Paraskevas
  fullname: Paraskevas, George P
  organization: 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, "Attikon" University General Hospital, 12462 Athens, Greece
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35453527$$D View this record in MEDLINE/PubMed
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Issue 4
Keywords Alzheimer’s disease
type 2 diabetes mellitus
common mechanisms
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Snippet Alzheimer's disease is the most common type of dementia, reaching 60-80% of case totals, and is one of the major global causes of the elderly population's...
Alzheimer’s disease is the most common type of dementia, reaching 60–80% of case totals, and is one of the major global causes of the elderly population’s...
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SubjectTerms Alzheimer's disease
Autophagy
Bias
Cognitive ability
common mechanisms
Dementia
Dementia disorders
Diabetes
Diabetes mellitus (non-insulin dependent)
Epidemiology
Genes
Glucose
Hyperglycemia
Inflammation
Insulin resistance
Meta-analysis
Metabolism
Mutation
Neurodegenerative diseases
Plasma
Proteins
Risk factors
Systematic Review
type 2 diabetes mellitus
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Title Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease: Review and Meta-Analysis
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