Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation

Innate lymphoid cells (ILCs) play an important role in the control and maintenance of barrier immunity. However, chronic activation of ILCs results in immune-mediated pathology. Here, we show that tissue-resident type 2 ILCs (ILC2s) display a distinct metabolic signature upon chronic activation. In...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 52; no. 4; pp. 620 - 634.e6
Main Authors:	Karagiannis, Fotios, Masouleh, Schekufe Kharabi, Wunderling, Klaus, Surendar, Jayagopi, Schmitt, Vanessa, Kazakov, Alexander, Michla, Marcel, Hölzel, Michael, Thiele, Christoph, Wilhelm, Christoph
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 14-04-2020 Elsevier Limited
Subjects:	Ablation Activation airway inflammation Allergens Asthma Cytokines Dgat1 Diet Droplets Enzymes Fatty acids Glucose High fat diet Inflammation innate lymphoid cells Interleukins Ketogenesis ketogenic diet lipid droplets Lipid metabolism Lipids Low carbohydrate diet Lymphoid cells Metabolic rate Metabolism Peroxisome proliferator-activated receptors Phospholipids Pparg Respiratory tract Respiratory tract diseases TOR protein airway inflammation fatty acids ketogenic diet Dgat1 metabolism innate lymphoid cells lipid droplets Pparg
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