Preserved Insulin Secretion and Insulin Independence in Recipients of Islet Autografts

• Published in: The New England journal of medicine Vol. 327; no. 4; pp. 220 - 226
• Main Authors: Pyzdrowski, Kathryn L, Kendall, David M, Halter, Jeffrey B, Nakhleh, Raouf E, Sutherland, David E.R, Robertson, R. Paul
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 23-07-1992
• Subjects: Adolescent; Adult; Arginine; Autografts; Biological and medical sciences; Biopsy; Blood Glucose - analysis; Catheterization; Chronic Disease; Diabetes; Diabetes mellitus; Epinephrine; Female; Glucagon; Glucagon - blood; Glucose; Glycated Hemoglobin A - analysis; Hemoglobin; Hepatic vein; Hormones; Humans; Hypoglycemia; Hypoglycemia - blood; Insulin; Insulin - metabolism; Insulin Secretion; Intravenous administration; Intubation; Islet cells; Islets of Langerhans - physiology; Islets of Langerhans Transplantation; Liver - cytology; Male; Medical sciences; Pain; Pancreas; Pancreatectomy; Pancreatic islet transplantation; Pancreatic Polypeptide - metabolism; Pancreatitis; Pancreatitis - physiopathology; Pancreatitis - surgery; Polypeptides; Portal vein; Rodents; Somatostatin; Spleen; Splenic artery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Transplantation, Autologous; Veins & arteries; Human; Autograft; Treatment; Secretion; Langerhans islet; Digestive diseases; Graft surgical; Insulin; Pancreatic disease
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199207233270402

THE amelioration of diabetes mellitus by the transplantation of pancreatic islets in animals has generated enthusiasm for the use of this procedure in humans with diabetes mellitus. If successful, islet transplantation would have advantages over transplantation of the entire pancreas. The procedure is shorter and easier, and the use of islets alone avoids the problem of exocrine drainage presented by the pancreatic allograft. However, there are only a few reports of transient successful transplantation of cadaveric islets in humans,
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and information about the secretion of hormones by the islets after successful transplantation is scant. Do the various types of islet . . .