Reverse phase protein microarrays quantify and validate the bioenergetic signature as biomarker in colorectal cancer

• Published in: Cancer letters Vol. 311; no. 2; pp. 210 - 218
• Main Authors: Aldea, M, Clofent, J, Núñez de Arenas, C, Chamorro, M, Velasco, M, Berrendero, J.R, Navarro, C, Cuezva, J.M
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 08-12-2011; Elsevier Limited
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Aged; ATP synthase; Bioenergetics; biomarkers; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Biopsy; Cancer therapies; Colorectal cancer; colorectal neoplasms; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Energy metabolism; Energy Metabolism - physiology; Female; Glycolysis; Hematology, Oncology and Palliative Medicine; Histology; Humans; Kaplan-Meier Estimate; Kinases; Male; Medical prognosis; Metabolism; microarray technology; Middle Aged; Mitochondria; Neoplasm Staging; Patients; phenotype; Predictive markers; Prognosis; Prognostic markers; Proportional Hazards Models; Protein Array Analysis - methods; Protein arrays; Proteins; proteome; Tumors; Prognostic markers; Glycolysis; ATP synthase; Energy metabolism; Mitochondria; Predictive markers
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2011.07.022

Highlights ► We report the quantity of proteins of energy metabolism in colon carcinomas. ► Colorectal carcinomas show a profound shift towards an enhanced glycolysis. ► The bioenergetic signature discriminates patients with bad or good prognosis. ► The bioenergetic signature is a relevant biomarker in colorectal cancer. ► The application of protein microarray technology is encouraged in cancer studies.