Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans

Coadministration of gemfibrozil (600 mg, b.i.d., 3 days) with pravastatin (40 mg/day) decreased the renal clearance of pravastatin by approximately 40% in healthy volunteers. To investigate the mechanism of this drug-drug interaction in the renal excretion process, we undertook an uptake study of pr...

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Bibliographic Details
Published in:	Xenobiotica Vol. 37; no. 4; pp. 416 - 426
Main Authors:	Nakagomi-Hagihara, R., Nakai, D., Tokui, T.
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 01-04-2007 Taylor & Francis
Subjects:	Animals Anticholesteremic Agents - antagonists & inhibitors Anticholesteremic Agents - metabolism Anticholesteremic Agents - pharmacology Cell Line, Transformed Dose-Response Relationship, Drug Drug Antagonism drug-drug interaction gemfibrozil Gemfibrozil - antagonists & inhibitors Gemfibrozil - pharmacology Humans Kidney - cytology Kidney - metabolism Mice Mice, Transgenic OAT Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors Organic Anion Transporters, Sodium-Independent - genetics Organic Anion Transporters, Sodium-Independent - metabolism Pravastatin Pravastatin - antagonists & inhibitors Pravastatin - metabolism Pravastatin - pharmacology
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