Cancer-Associated Fibroblasts Accelerate Malignant Progression of Non-Small Cell Lung Cancer via Connexin 43-Formed Unidirectional Gap Junctional Intercellular Communication

Background/Aims: Gap junctions, which are assembled by connexins, can directly connect the cytoplasm of adjacent cells and enable gap junctional intercellular communication (GJIC) as well as metabolic coupling between neighboring cells. Here, we investigated the role of connexin 43 (Cx43) and its de...

Full description

Saved in:

Bibliographic Details
Published in:	Cellular physiology and biochemistry Vol. 51; no. 1; pp. 315 - 336
Main Authors:	Luo, Min, Luo, Yanmei, Mao, Naiquan, Huang, Guolin, Teng, Cuifang, Wang, Hanlin, Wu, Junwei, Liao, Xiaoli, Yang, Jie
Format:	Journal Article
Language:	English
Published:	Basel, Switzerland S. Karger AG 01-01-2018 Cell Physiol Biochem Press GmbH & Co KG
Subjects:	Adenosine Triphosphate - metabolism Antibiotics Cadherins - metabolism Cancer-associated fibroblasts Cancer-Associated Fibroblasts - cytology Cancer-Associated Fibroblasts - metabolism Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Cell cycle Cell Line, Tumor Cell Movement Collagen Communication Connexin 43 Connexin 43 - antagonists & inhibitors Connexin 43 - genetics Connexin 43 - metabolism Cooperation Epithelial-Mesenchymal Transition Female Fibroblasts Gap Junctions - metabolism Humans Immunoglobulins Kaplan-Meier Estimate Kinases Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Male Malignant progression Medical prognosis Metabolic coupling Metabolism Metabolites Metastasis Middle Aged Non-small cell lung cancer Original Paper Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Prostate cancer Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism RNA Interference RNA, Small Interfering - metabolism Signal Transduction Stem cells Unidirectional gap junctional intercellular communication United States > US China Cancer-associated fibroblasts Metabolic coupling Connexin 43 Unidirectional gap junctional intercellular communication Malignant progression Non-small cell lung cancer
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!