New in vitro findings about halogenated boroxine cytotoxicity and deregulation of cell death-related genes in GR-M melanoma cells

Anti-proliferative effects of halogenated boroxine – K (B OH) (HB) – have been confirmed in multiple cancer cell lines, including melanoma, but the exact mechanism of action is still unknown. This study aimed to determine its cytotoxic effects on human Caucasian melanoma (GR-M) cell growth as well a...

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Bibliographic Details
Published in:	Arhiv za higijenu rada i toksikologiju Vol. 74; no. 1; pp. 16 - 21
Main Authors:	Elez-Burnjaković, Nikolina, Pojskić, Lejla, Haverić, Anja, Lojo-Kadrić, Naida, Omanović, Maida Hadžić, Ramić, Jasmin, Smajlović, Ajla, Maksimović, Milka, Haverić, Sanin
Format:	Journal Article
Language:	English
Published:	Croatia Sciendo 01-03-2023 Institute for Medical Research and Occupational Health
Subjects:	anti-proliferative effect antiproliferativni učinak Apoptosis Autophagy bcl-2 Bcl-2 protein becn1, dram1 Blood Cell Death Cell growth Cell Line, Tumor Cytotoxicity Deregulation Fluorometers Gene expression Genes human Caucasian melanoma Humans Immune checkpoint inhibitors Immunosuppressive agents Leukocytes, Mononuclear - pathology ljudski kavkaski melanom Medical prognosis Melanocytes Melanoma Melanoma - genetics Melanoma - pathology mononuklearne stanice periferne krvi Mortality Mutation Original Peripheral blood peripheral blood mononuclear cell Proteins Proto-Oncogene Proteins c-bcl-2 - pharmacology Qubits (quantum computing) Ribonucleic acid RNA Sequestosome-1 Protein Skin cancer sqstm1 Toxicity Variance analysis White people St Louis Missouri United Kingdom > UK United States > US Germany anti-proliferative effect BCL-2 antiproliferativni učinak human Caucasian melanoma ljudski kavkaski melanom SQSTM1 mononuklearne stanice periferne krvi BECN1, DRAM1 peripheral blood mononuclear cell
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