Validation of an orthotopic model of human lung cancer with regional and systemic metastases

Background. We developed an orthotopic model of human lung cancer that exhibits highly predictable regional and systemic metastases. This study examines the response of the model when treated with conventional and experimental chemotherapy. Methods. NCI-H460 tumor fragments were implanted into the r...

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Bibliographic Details
Published in:	The Annals of thoracic surgery Vol. 71; no. 4; pp. 1120 - 1125
Main Authors:	Johnston, Michael R, Mullen, John B.M, Pagura, Marco E, Howard, Randy B
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-04-2001 Elsevier Science
Subjects:	Analysis of Variance Animals Antineoplastic Agents - pharmacology Biological and medical sciences Carcinoma, Large Cell - drug therapy Carcinoma, Large Cell - secondary Cisplatin - pharmacology Disease Models, Animal Doxorubicin - pharmacology Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Medical sciences Mitomycin - pharmacology Neoplasm Invasiveness Neoplasm Transplantation Phenylalanine - analogs & derivatives Phenylalanine - pharmacology Pneumology Rats Rats, Nude Survival Rate Thiophenes - pharmacology Treatment Outcome Tumors of the respiratory system and mediastinum Xenograft Model Antitumor Assays - standards Antineoplastic agent Animal model Rat Toxicity Metalloendopeptidases Metastasis Doxorubicin Bronchopulmonary Isomerases Bronchus disease Complication Batimastat Platinum II Complexes DNA topoisomerase (ATP-hydrolysing) Lung disease Mitomycin Pathophysiology Respiratory disease Enzyme Treatment efficiency Rodentia Enzyme inhibitor Exploration Malignant tumor Cisplatin Peptidases Alkylating agent Vertebrata Chemotherapy Mammalia Treatment Hydrolases Anthracyclins Comparative study
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