Repeated Measurements Are Necessary for Evaluating Accurate Diurnal Rhythm Using a Self-Intraocular Pressure Measurement Device

• Published in: Journal of clinical medicine Vol. 12; no. 7; p. 2460
• Main Authors: Shigemoto, Yumi, Hasebe, Yuka, Kitamura, Kazuyoshi, Fukuda, Yoshiko, Sakamoto, Masako, Matsubara, Mio, Minaguchi, Shinya, Kashiwagi, Kenji
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23-03-2023; MDPI
• Subjects: Brief Report; Circadian rhythms; Clinical medicine; Diagnosis; Eye; Glaucoma; Health aspects; Intraocular pressure; Investigations; Measurement; Medical examination; Open-angle glaucoma; Reproducibility; Statistical analysis; Values; Japan; Finland; self-measurement; diurnal rhythm; intraocular pressure; glaucoma; reproducibility
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12072460

To investigate how many tests need to be performed to adequately assess intraocular pressure (IOP) diurnal change using a self-measuring rebound tonometer among glaucoma patients.
Adult patients with primary open-angle glaucoma were included. IOP was measured in the morning (6 AM to 9 AM), afternoon (12 PM to 3 PM), and at night (6 PM to 9 PM) for seven consecutive days. Twenty-four (7 males and 17 females, mean age 59.5 ± 11.0 years) patients who successfully measured IOP at least three times per day during the correct time periods for four days were subjected to analysis.
The IOP rhythm was significantly greater on the first day of measurement (6.6 ± 3.6 mmHg) than that averaged during subsequent days (4.4 ± 2.2 mmHg). The time of the highest and lowest IOP measurements on the first day of IOP measurement and during the entire measurement period coincided in 72.9% and 64.6% of cases, respectively. The concordance rate of the highest IOP time between the whole measurement period and each measurement day was less than 60%.
The diurnal IOP rhythm measured by the patients themselves was not consistent, and multiple days of measurements may be necessary to correctly assess diurnal IOP rhythm.