MYC and gastric adenocarcinoma carcinogenesis

MYC is an oncogene involved in cell cycle regulation, cell growth arrest, cell adhesion, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association betwee...

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Published in:	World journal of gastroenterology : WJG Vol. 14; no. 39; pp. 5962 - 5968
Main Authors:	Calcagno, Danielle-Queiroz, Leal, Mariana-Ferreira, Assumpcao, Paulo-Pimentel, Smith, Marilia-Arruda-Cardoso, Burbano, Rommel-Rodriguez
Format:	Journal Article
Language:	English
Published:	United States Human Cytogenetics Laboratory, Biology Science Institute, Federal University of Para, Belem PA 66075-900, Brazil%Genetics Division, Department of Morphology and Genetics,Federal University of Sao Paulo, Sao Paulo SP 04023-900, Brazil%Joao de Barros Barreto University Hospital, Federal University of Para, Belem PA 66073-000, Brazil 21-10-2008 The WJG Press and Baishideng
Subjects:	Adenocarcinoma - genetics Adenocarcinoma - microbiology Cell Transformation, Neoplastic Gene Expression Regulation, Neoplastic - physiology Genes, myc - genetics Genes, myc - physiology Helicobacter pylori - physiology Humans Review Stomach Neoplasms - genetics Stomach Neoplasms - microbiology 治疗方法病理机制肿瘤形成 Gastricpreneoplastic lesions,Gastric carcinogenesis Gastric adenocarcinoma Gastric carcinogenesis Helicobacter pylori MYC Helicobacter pyloripreneoplastic lesions
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Summary:	MYC is an oncogene involved in cell cycle regulation, cell growth arrest, cell adhesion, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. In the present review, we focus on the deregulation of the MYC oncogene in gastric adenocarcinoma carcinogenesis, including its association with Helicobacterpylori （Hpylon] and clinical applications.
Bibliography:	Gastric preneoplastic lesions MYC; Gastric adenocarcinoma; Gastric preneoplastic lesions; Gastric carcinogenesis;Helicobacter pylori Helicobacter pylori 14-1219/R MYC R735.2 Gastric adenocarcinoma Gastric carcinogenesis Telephone: +55-91-32429254 Fax: +55-91-32111601 Author contributions: Calcagno DQ, Leal MF, Assumpção PP, Smith MAC and Burbano RR contributed equally to this work; the authors wrote the paper based on results of their own experience and recent literature sources (PubMed, ISI Web of Science) on gastric cancer. Correspondence to: Rommel Rodríguez Burbano, Laboratório de Citogenética Humana, Departamento de Biologia, Instituto de Ciências Biológicas, Campus Universitário do Guamá/Universidade Federal do Pará, Av. Augusto Correa 01, Belém, PA 66075-900, Brazil. rommel@ufpa.br
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.14.5962