All-trans-Retinoic Acid Prevents Radiation- or Bleomycin-induced Pulmonary Fibrosis

Although radiotherapy is effective in treating lung cancers, resultant pulmonary injury is the main obstacle. Pulmonary fibrosis is characterized by progressive worsening in pulmonary function leading to high incidence of death. Currently, however, there has been little progress in effective prevent...

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Bibliographic Details
Published in:	American journal of respiratory and critical care medicine Vol. 174; no. 12; pp. 1352 - 1360
Main Authors:	Tabata, Chiharu, Kadokawa, Yoshio, Tabata, Rie, Takahashi, Meiko, Okoshi, Kae, Sakai, Yoshiharu, Mishima, Michiaki, Kubo, Hajime
Format:	Journal Article
Language:	English
Published:	New York, NY Am Thoracic Soc 15-12-2006 American Lung Association American Thoracic Society
Subjects:	Acids Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antineoplastic agents Biological and medical sciences Bleomycin - adverse effects Cancer therapies Cell growth Cells, Cultured Chemotherapy Collagen Collagen - biosynthesis Collagen Type I - analysis Cytokines Female Fibroblasts Fluorescent Antibody Technique Gamma rays Growth factors Humans Intensive care medicine Interleukin-6 - analysis Kinases Laboratory animals Leukemia Lung - chemistry Lung - drug effects Lung - radiation effects Lung cancer Lung diseases Medical research Medical sciences Mice Mice, Inbred C57BL Mortality Pharmacology. Drug treatments Pneumology Polymerase chain reaction Proteins Pulmonary arteries Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - etiology Pulmonary Fibrosis - pathology Pulmonary Fibrosis - prevention & control Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Radiation therapy Transforming Growth Factor beta1 - analysis Tretinoin - therapeutic use Tumor necrosis factor-TNF Japan Antineoplastic agent Lung disease Intensive care Peptides Respiratory disease Retinoid Cytokine Antibiotic Bleomycin Pulmonary fibrosis Glycopeptide interstitial lung disease lung fibroblasts Interstitial pneumonitis cytokines Fibroblast Resuscitation Tretinoin
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