The effect of platelet rich plasma on angiogenesis in ischemic flaps in VEGFR2-luc mice

Abstract To improve skin flap healing, one promising strategy in reconstructive surgery might be to optimize platelet rich plasma (PRP) bioactivity and the ischemia-altered expression of genes. We studied both the effect of PRP on ischemic flaps, and whether in vivo bioluminescence imaging (BLI) is...

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Bibliographic Details
Published in:	Biomaterials Vol. 34; no. 11; pp. 2674 - 2682
Main Authors:	Sönmez, Tolga Taha, Vinogradov, Alexandra, Zor, Fatih, Kweider, Nisreen, Lippross, Sebastian, Liehn, Elisa Anamaria, Naziroglu, Mustafa, Hölzle, Frank, Wruck, Christoph, Pufe, Thomas, Tohidnezhad, Mersedeh
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-04-2013
Subjects:	Advanced Basic Science Animals Bioluminescence imaging Cell Survival Dentistry Enzyme-Linked Immunosorbent Assay Free flap Gene Expression Immunohistochemistry Ischemia Ischemia - pathology Luminescent Measurements Mice Mice, Transgenic Neovascularization, Physiologic Platelet rich plasma Platelet-Rich Plasma - metabolism Surgical Flaps - blood supply Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF VEGFR2 Wound Healing VEGFR2 Platelet rich plasma Bioluminescence imaging Ischemia VEGF Free flap
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