Induction of neutralizing antibodies in mice immunized with an amino-terminal polypeptide of Streptococcus mutans P1 protein produced by a recombinant Bacillus subtilis strain

Abstract The oral pathogen Streptococcus mutans expresses a surface protein, P1, which interacts with the salivary pellicle on the tooth surface or with fluid-phase saliva, resulting in bacterial adhesion or aggregation, respectively. P1 is a target of protective immunity. Its N-terminal region has...

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Bibliographic Details
Published in:	FEMS immunology and medical microbiology Vol. 59; no. 2; pp. 131 - 142
Main Authors:	Tavares, Milene B., Silva, Bruno M., Cavalcante, Rafael C.M., Souza, Renata D., Luiz, Wilson B., Paccez, Juliano D., Crowley, Paula J., Brady, L. Jeannine, Ferreira, Luís C.S., Ferreira, Rita C.C.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-07-2010 Blackwell
Subjects:	Adhesins, Bacterial - genetics Adhesins, Bacterial - immunology Animals Antibodies, Bacterial - blood Antibodies, Neutralizing - blood antibody responses Bacillus subtilis Bacillus subtilis - genetics Bacterial Adhesion - immunology Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetic Vectors Mice Mice, Inbred BALB C Microbiology Miscellaneous P1 protein recombinant proteins Recombinant Proteins - genetics Recombinant Proteins - immunology saliva‐binding region Streptococcus mutans Streptococcus mutans - genetics Streptococcus mutans - immunology recombinant proteins P1 protein saliva-binding region antibody responses Immunization Immune response Bacillus subtilis Rodentia Bacillaceae Neutralizing antibody Strain Streptococcus mutans Streptococcaceae Vertebrata Mammalia Immunology Bacillales Mouse Polypeptide Bacteria Micrococcales Recombinant protein Saliva Humoral immunity
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