Proliferative activity in peripheral ossifying fibroma and ossifying fibroma

• Published in: Journal of oral pathology & medicine Vol. 27; no. 2; pp. 64 - 67
• Main Authors: Mesquita, Ricardo Alves, Orsini, Suzana Catanhede, Sousa, Machado, de Araujo, Ney Soares
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-02-1998; Blackwell
• Subjects: AgNOR staining; Antibodies, Monoclonal; Biological and medical sciences; Cell Division; Cell Nucleus - ultrastructure; Coloring Agents; Dentistry; Ent. Stomatology; Fibroblasts - pathology; Fibroma - pathology; Fibroma, Ossifying - pathology; Gingival Neoplasms - pathology; Humans; Immunohistochemistry; immunohistochemisty; Investigative techniques, diagnostic techniques (general aspects); Jaw Neoplasms - pathology; Macrophages - pathology; Medical sciences; Nucleolus Organizer Region - ultrastructure; ossifying fibroma; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; peripheral ossifying fibroma; proliferating cell nuclear antigen; Proliferating Cell Nuclear Antigen - analysis; Silver; Human; Immunohistochemistry; Stomatology; Diseases of the osteoarticular system; Maxillary; Nucleolus organizer region; Activity; Exploration; Proliferation; Pathology; Ossifying fibroma; Benign neoplasm; PCNA antigen; Comparative study; Bibliographic review; Maxillary disease
• ISSN: 0904-2512; 1600-0714
• DOI: 10.1111/j.1600-0714.1998.tb02095.x

Mesquita RA, Sousa SCOM, Araujo NS: Proliferative activity in peripheral ossifying fibroma and ossifying fibroma. J Oral Pathol Med 1998; 27: 64–7. © Munksgaard, 1998.
A proliferative activity study analysing morphometric and quantitative aspects of nucleolar organizer regions (NORs) and proliferating cell nuclear antigen (PCNA) expression was conducted in 10 cases of peripheral ossifying fibroma (POF) and 10 cases of ossifying fibroma (OF). For NOR identification, the silver staining technique (AgNOR technique) was used. PCNA expression was determined by immunohistochemical staining using the PC 10 antibody. The AgNOR analysis for the two lesions showed a profile characteristic of benign lesions. OF showed higher AgNOR number and PCNA expression than POF. Our results suggest increased proliferative activity in OF compared with POF.