Exercise blood pressure response is related to left ventricular mass

• Published in: Journal of human hypertension Vol. 17; no. 5; pp. 333 - 338
• Main Authors: SUNG, J, OUYANG, P, SILBER, H. A, BACHER, A. C, TURNER, K. L, DEREGIS, J. R, HEES, P. S, SHAPIRO, E. P, STEWART, K. J
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 01-05-2003; Nature Publishing Group
• Subjects: Aged; Biological and medical sciences; Blood pressure; Blood Pressure - physiology; Body Composition - physiology; Body mass; Body Mass Index; Cardiovascular diseases; Cardiovascular system; Care and treatment; Diagnosis; Diastole - physiology; Dual energy X-ray absorptiometry; Exercise - physiology; Exercise Test; Female; Heart; Heart Rate - physiology; Heart Ventricles - anatomy & histology; Heart Ventricles - physiopathology; Humans; Hypertension; Hypertension - physiopathology; Hypertrophy; Hypertrophy, Left Ventricular - physiopathology; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Lean body mass; Magnetic resonance imaging; Male; Medical sciences; Middle Aged; Multivariate Analysis; Organ Size; Oxygen Consumption - physiology; Patient outcomes; Physiological aspects; Predictive Value of Tests; Prognosis; Sex Factors; Statistics as Topic; Systole - physiology; Ventricle; Treadmill exercise; Physical exercise; Human; Exploration; exercise; Nuclear magnetic resonance imaging; left ventricular mass; Left ventricle; Mass; Medical imagery; Blood pressure; Circulatory system; Hemodynamics
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/sj.jhh.1001552

An exaggerated SBP response to exercise has been associated with increased left ventricular (LV) mass in some but not all studies. A total of 43 women and 34 men, aged 55-75 years, without evidence of cardiovascular disease, with a mean resting BP of 142+/-9/77+/-8 mmHg had their BP measured at rest and during maximal treadmill exercise. LV mass was measured using magnetic resonance imaging. LV mass was adjusted for lean body mass, which was assessed by dual energy X-ray absorptiometry. LV mass was within the normal range for the majority of the subjects. Among the resting and exercise BP indices, maximal SBP was the strongest correlate of LV mass (r=0.41, P<0.05). In multivariate analysis, maximal SBP was independently associated with LV mass after adjustment for lean body mass and gender, explaining 3% of the variance (P<0.05). Maximal exercise SBP is a modest but still independent predictor of LV mass in older persons with normal LV mass. These results raise the possibility that the SBP response to maximal exercise is an early marker of LV hypertrophy.