Claudin 1 Expression Characterizes Human Uterine Cervical Reserve Cells
Stem cells participate in cervical carcinogenesis but their function and exact features are still not clear. One type of stem-like cells are endocervical reserve cells (RCs), and their association with other normal/altered cervical cells is not exactly known. Epithelial cells are attached to each ot...
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| Published in: | The journal of histochemistry and cytochemistry Vol. 61; no. 12; pp. 880 - 888 |
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| Abstract | Stem cells participate in cervical carcinogenesis but their function and exact features are still not clear. One type of stem-like cells are endocervical reserve cells (RCs), and their association with other normal/altered cervical cells is not exactly known. Epithelial cells are attached to each other by tight junctions. Their dominant components are the claudin proteins, which show changed expression in cancer; however, no data are available on their pattern. Expressions of various claudins (1, 2, 3, 4, 7), occludin, cytokeratins 5/6 and 7, and p63 were analyzed in 60 paraffin-embedded cervical samples. Immunohistochemical reactions were evaluated semiquantitatively and statistically. Claudin 1 was as high in RCs as in cervical intraepithelial neoplasia (CIN) and higher than in suprabasal squamous epithelial cells, contrary to the negative glandular and squamous basal cells. Claudin 2 was positive in all cell types except parabasal cells, whereas claudins 4 and 7 were weakly positive and claudin 3 was negative in all cell types. Occludin was positive in RCs, basal/parabasal cells, and CIN, whereas glandular cells were negative. This is a first report that describes the intermediate claudin pattern of RCs, demonstrating that it differs from that of cervical glandular and squamous basal cells, but showing an expression similar to the strong claudin 1 expression detected in cervical neoplastic cells. |
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| AbstractList | Stem cells participate in cervical carcinogenesis but their function and exact features are still not clear. One type of stem-like cells are endocervical reserve cells (RCs), and their association with other normal/altered cervical cells is not exactly known. Epithelial cells are attached to each other by tight junctions. Their dominant components are the claudin proteins, which show changed expression in cancer; however, no data are available on their pattern. Expressions of various claudins (1, 2, 3, 4, 7), occludin, cytokeratins 5/6 and 7, and p63 were analyzed in 60 paraffin-embedded cervical samples. Immunohistochemical reactions were evaluated semiquantitatively and statistically. Claudin 1 was as high in RCs as in cervical intraepithelial neoplasia (CIN) and higher than in suprabasal squamous epithelial cells, contrary to the negative glandular and squamous basal cells. Claudin 2 was positive in all cell types except parabasal cells, whereas claudins 4 and 7 were weakly positive and claudin 3 was negative in all cell types. Occludin was positive in RCs, basal/parabasal cells, and CIN, whereas glandular cells were negative. This is a first report that describes the intermediate claudin pattern of RCs, demonstrating that it differs from that of cervical glandular and squamous basal cells, but showing an expression similar to the strong claudin 1 expression detected in cervical neoplastic cells. |
| Author | Kiss, András Sobel, Gábor Babarczi, Edit Zinner, Balázs Gyöngyösi, Benedek |
| AuthorAffiliation | 2nd Department of Pathology (BG,AK), Semmelweis University, Budapest, Hungary Department of Pathology, St. Stephan Hospital, Budapest, Hungary (EB) 2nd Department of Obstetrics and Gynecology (BZ,GS), Semmelweis University, Budapest, Hungary |
| AuthorAffiliation_xml | – name: Department of Pathology, St. Stephan Hospital, Budapest, Hungary (EB) – name: 2nd Department of Pathology (BG,AK), Semmelweis University, Budapest, Hungary – name: 2nd Department of Obstetrics and Gynecology (BZ,GS), Semmelweis University, Budapest, Hungary |
| Author_xml | – sequence: 1 givenname: Balázs surname: Zinner fullname: Zinner, Balázs – sequence: 2 givenname: Benedek surname: Gyöngyösi fullname: Gyöngyösi, Benedek – sequence: 3 givenname: Edit surname: Babarczi fullname: Babarczi, Edit – sequence: 4 givenname: András surname: Kiss fullname: Kiss, András – sequence: 5 givenname: Gábor surname: Sobel fullname: Sobel, Gábor email: sobelg@gmail.com |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23900598$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_lary_30845 crossref_primary_10_3389_fgene_2018_00544 crossref_primary_10_3892_ijo_2020_5105 crossref_primary_10_1007_s12253_014_9871_x crossref_primary_10_17537_2019_14_160 crossref_primary_10_1016_j_clinbiochem_2016_08_004 crossref_primary_10_4168_aair_2023_15_4_512 crossref_primary_10_18632_oncotarget_16783 |
| Cites_doi | 10.1016/j.febslet.2011.01.028 10.1016/j.ygyno.2006.04.005 10.1007/BF03032402 10.1016/j.humpath.2004.10.017 10.1097/PGP.0b013e31819932f8 10.1186/1471-2407-6-186 10.1016/j.humpath.2004.12.001 10.1080/09513590802242694 10.1016/j.humpath.2012.03.023 10.1155/2010/541957 10.1007/s00018-006-6314-1 10.1242/jcs.023887 10.1158/0008-5472.CAN-05-2782 10.1016/B978-0-443-07477-6.50011-1 10.1038/onc.2008.344 10.1007/s00418-008-0424-9 10.1016/j.humpath.2007.10.002 10.1016/j.ygyno.2004.11.058 10.1038/modpathol.3800549 10.1101/cshperspect.a002907 10.2741/3736 10.1111/j.1365-2559.2007.02652.x 10.1007/s00428-007-0406-7 10.1111/j.1365-2559.2012.04189.x |
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| Keywords | reserve cells claudin 1 tight junction |
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| Snippet | Stem cells participate in cervical carcinogenesis but their function and exact features are still not clear. One type of stem-like cells are endocervical... |
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| SubjectTerms | Cervix Uteri - cytology Cervix Uteri - metabolism Cervix Uteri - pathology Claudin-1 - analysis Claudin-1 - biosynthesis Female Humans Immunohistochemistry |
| Title | Claudin 1 Expression Characterizes Human Uterine Cervical Reserve Cells |
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