Kinetics of DSB rejoining and formation of simple chromosome exchange aberrations

Purpose : To investigate the role of kinetics in the processing of DNA double strand breaks (DSB), and the formation of simple chromosome exchange aberrations following X-ray exposures to mammalian cells based on an enzymatic approach. Methods : Using computer simulations based on a biochemical appr...

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Bibliographic Details
Published in:	International journal of radiation biology Vol. 76; no. 11; pp. 1463 - 1474
Main Authors:	Cucinotta, F. A., Nikjoo, H., O'Neill, P., Goodhead, D. T.
Format:	Journal Article
Language:	English
Published:	Legacy CDMS Informa UK Ltd 2000 Taylor & Francis
Subjects:	Animals Biological and medical sciences Chromosome Aberrations Computer Simulation DNA - genetics DNA - metabolism DNA - radiation effects DNA Damage DNA Repair Fundamental and applied biological sciences. Psychology Humans Kinetics Life Sciences (General) Medicin och hälsovetenskap Models, Biological Molecular and cellular biology Molecular genetics Mutagenesis. Repair Nonlinear Dynamics Recombination, Genetic Space life sciences Chromosomal aberration Double strand break Cell culture Kinetic model Ionizing radiation DNA Radiation injury Biological effect Mechanism of action Repair In vitro X ray irradiation
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