Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis

: Heparanase is a heparan sulphate endo‐glycosidase which was previously detected in the outer root sheath of murine hair follicles. Heparanase overexpression was reported to improve mouse hair (re)growth. In this study, we investigated its involvement in human hair biology. Immunofluorescence dete...

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Bibliographic Details
Published in:	Experimental dermatology Vol. 17; no. 12; pp. 1017 - 1023
Main Authors:	Malgouries, Sylvain, Donovan, Mark, Thibaut, Sébastien, Bernard, Bruno A.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-12-2008 Blackwell
Subjects:	Aged Biological and medical sciences Cell Differentiation - physiology Dermatology Desmoglein 1 - metabolism Enzyme Inhibitors - pharmacology Epidermis - metabolism Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Female Fibronectins - metabolism hair Hair Follicle - cytology Hair Follicle - drug effects Hair Follicle - physiology heparan sulfate heparanase 1 Heparin Lyase - antagonists & inhibitors Heparin Lyase - metabolism Heparitin Sulfate - metabolism Homeostasis - physiology Humans Immunohistochemistry inner root sheath Keratin-14 - metabolism Keratins, Hair-Specific - metabolism Keratins, Type I - metabolism Ki-67 Antigen - metabolism Medical sciences Middle Aged Tissue Culture Techniques Transglutaminases - metabolism Hair Program Dermatology Homeostasis Hair follicle heparanase 1 Cell differentiation Sheath Hair (head) heparan sulfate Heparanase Heparitin sulfate inner root sheath Differentiation
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