Ferulic acid, a natural protector against carbon tetrachloride-induced toxicity

• Published in: Fundamental & clinical pharmacology Vol. 19; no. 4; pp. 491 - 496
• Main Authors: Srinivasan, M., Rukkumani, R., Ram Sudheer, A., Menon, Venugopal P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01-08-2005; Blackwell
• Subjects: Animals; antioxidants; Antioxidants - pharmacology; Biological and medical sciences; Carbon Tetrachloride - toxicity; CCl4; Coumaric Acids - pharmacology; Female; ferulic acid; Glutathione - analysis; lipid peroxidation; Lipid Peroxidation - drug effects; Liver - drug effects; Liver - metabolism; liver fibrosis; Medical sciences; Nitric Oxide - analysis; Pharmacology. Drug treatments; Rats; Rats, Wistar; Digestive system; Toxicity; Liver; Carbon tetrachloride; Lipids; Antioxidant; lipid peroxidation; Prevention; liver fibrosis; Acids; Fibrosis; antioxidants. CCl4. ferulic acid; Peroxidation
• ISSN: 0767-3981; 1472-8206
• DOI: 10.1111/j.1472-8206.2005.00332.x

The present work is aimed at evaluating the protective effect of ferulic acid (FA), a naturally occurring phenolic compound on CCl4 induced toxicity. The activities of liver markers (alanine transaminase, aspartate transaminase, alkaline phosphatase, γ‐glutamyl transferase), lipid peroxidative index (thiobarbituric acid‐reactive substances, hydroperoxides, nitric oxide, protein carbonyl content), the antioxidant status (superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione) were used as biomarkers to monitor the protective role of FA. The liver marker enzymes in plasma and lipid peroxidative index in liver and kidney were increased in CCl4‐treated groups, which were decreased significantly on treatment with FA. The antioxidants, which were depleted in CCl4‐treated groups, were improved significantly by FA treatment. Administration of FA to normal rats did not produce any harmful effects. Thus our results show that FA is an effective antioxidant without any side‐effects and may be a great gain in the current search for natural therapy.