Chemical Strategies for Activity-Based Proteomics

The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dy...

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Bibliographic Details
Published in:	Chembiochem : a European journal of chemical biology Vol. 5; no. 1; pp. 41 - 47
Main Authors:	Speers, Anna E, Cravatt, Benjamin F
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley-VCH Verlag 03-01-2004 WILEY-VCH Verlag WILEY‐VCH Verlag
Subjects:	activity-based profiling Animals Drug Delivery Systems Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology enzymes Enzymes - chemistry Humans inhibitors probes Protein Engineering proteomics Proteomics - methods Structure-Activity Relationship
Online Access:	Get full text
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Summary:	The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity-based protein profiling enable both the discovery and functional analysis of enzymes associated with human disease.
Bibliography:	http://dx.doi.org/10.1002/cbic.200300721 ArticleID:CBIC200300721 ark:/67375/WNG-ZG8Q4J7T-N istex:0524F7D16F3909DF224ACE6D27FE1CA15E637C0E ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-3 ObjectType-Review-2
ISSN:	1439-4227 1439-7633 1439-4227
DOI:	10.1002/cbic.200300721