Tc-99m HDP Bone Scan Showing Bone Changes in a Case of Tuberous Sclerosis or Bourneville’s Disease

• Published in: Clinical nuclear medicine Vol. 26; no. 1; pp. 50 - 52
• Main Authors: JONARD, PAUL, LONNEUX, MAX, BOLAND, BENOIT, MALGHEM, JACQUES, JAMAR, FRANÇOIS, D, M
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Lippincott Williams & Wilkins, Inc 01-01-2001; Hagerstown, MD Lippincott
• Subjects: Adult; Biological and medical sciences; Bone and Bones - diagnostic imaging; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Neurology; Osteoarticular system. Muscles; Radionuclide Imaging; Radionuclide investigations; Radiopharmaceuticals; Technetium Tc 99m Medronate - analogs & derivatives; Tuberous Sclerosis - diagnostic imaging; Tumors of the nervous system. Phacomatoses; Radionuclide study; Human; Nervous system diseases; Diseases of the osteoarticular system; Technetium; Radioactive tracers; Scintigraphy; Genetic disease; Case study; Medical imagery; Tumor; Adult; Female; Whole body; Diagnosis; Bone; Bourneville syndrome; Pharmacokinetics; Semiology
• ISSN: 0363-9762; 1536-0229
• DOI: 10.1097/00003072-200101000-00011

Whole-body Tc-99m HDP scintigraphy was performed in a 25-year-old woman with known tuberous sclerosis. The scintigraphic pattern showed multiple foci of abnormal activity over the hands, phalanges, feet, tibias, fibulas, ulnas, and radii, where radiographs showed periosteal apposition, irregular cortical thickening, and cyst-like lesions on the phalanges. The spine, pelvis, and ribs showed heterogeneous tracer uptake where radiographs showed patchy areas of increased bone density. This radiographic pattern is characteristic of osseous tuberous sclerosis. Although previous reports suggested the opposite conclusion, this observation indicates that an abnormal result of bone scintiscan can be observed in osseous tuberous sclerosis.