Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets

The atherosclerotic plaque microenvironment is highly complex, and selective agents that modulate plaque stability are not yet available. We sought to develop a scRNA-seq analysis workflow to investigate this environment and uncover potential therapeutic approaches. We designed a user-friendly, repr...

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Bibliographic Details
Published in:	Atherosclerosis Vol. 340; pp. 12 - 22
Main Authors:	Ma, Wei Feng, Hodonsky, Chani J., Turner, Adam W., Wong, Doris, Song, Yipei, Mosquera, Jose Verdezoto, Ligay, Alexandra V., Slenders, Lotte, Gancayco, Christina, Pan, Huize, Barrientos, Nelson B., Mai, David, Alencar, Gabriel F., Owsiany, Katherine, Owens, Gary K., Reilly, Muredach P., Li, Mingyao, Pasterkamp, Gerard, Mokry, Michal, van der Laan, Sander W., Khomtchouk, Bohdan B., Miller, Clint L.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-01-2022
Subjects:	Atherosclerosis Cardioinformatics Coronary Artery Disease - drug therapy Coronary Artery Disease - genetics Drug Discovery Gene Expression Profiling Humans Pharmaceutical Preparations Pipeline PlaqView Precision Medicine RNA-Seq scRNA Sequence Analysis, RNA Single-Cell Analysis Software Web Application Workflow Atherosclerosis scRNA PlaqView Web Application Cardioinformatics Drug Discovery Pipeline Precision Medicine
Online Access:	Get full text
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