Is Dosing of Ethambutol as Part of a Fixed-Dose Combination Product Optimal for Mechanically Ventilated ICU Patients with Tuberculosis? A Population Pharmacokinetic Study

Tuberculosis (TB) patients admitted to intensive care units (ICU) have high mortality rates. It is uncertain whether the pharmacokinetics of first-line TB drugs in ICU patients are different from outpatients. This study aims to compare the pharmacokinetics of oral ethambutol in TB patients in ICU ve...

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Bibliographic Details
Published in:	Antibiotics (Basel) Vol. 10; no. 12; p. 1559
Main Authors:	Beraldi-Magalhaes, Francisco, Parker, Suzanne L, Sanches, Cristina, Sousa Garcia, Leandro, Souza Carvalho, Brenda Karoline, Fachi, Mariana Millan, de Liz, Marcus Vinicius, Pontarolo, Roberto, Lipman, Jeffrey, Cordeiro-Santos, Marcelo, Roberts, Jason A
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 20-12-2021 MDPI
Subjects:	Absorption Bioavailability biological availability Creatinine critical care Dosage Drug dosages Ethambutol Exposure HIV Hospitals Human immunodeficiency virus Intensive care Intensive care units Minimum inhibitory concentration Mortality Oral administration Patients Pharmacokinetics Pharmacology Population studies Tuberculosis Ventilation critical care pharmacokinetics biological availability intensive care ethambutol tuberculosis
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