Pilot-scale synthesis and rheological assessment of poly(methyl methacrylate) polymers: Perspectives for medical application

• Published in: Materials Science & Engineering C Vol. 51; pp. 107 - 116
• Main Authors: Linan, Lamia Zuniga, Nascimento Lima, Nádson M., Filho, Rubens Maciel, Sabino, Marcos A., Kozlowski, Mark T., Manenti, Flavio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-06-2015
• Subjects: Assessments; Biocompatible Materials - analysis; Biocompatible Materials - chemical synthesis; Biomaterial; Bone Cements - analysis; Bone Cements - chemical synthesis; Elastic Modulus; Hot Temperature; Materials Testing; Medical; Molecular Weight; Pilot Projects; PMMA; Polymers; Polymethyl Methacrylate - analysis; Polymethyl Methacrylate - chemical synthesis; Polymethyl methacrylates; Pressure; Rheological properties; Synthesis; Viscoelastic properties; Viscoelasticity; Viscosity; Biomaterial; Synthesis; Viscoelastic properties; PMMA; Molecular weight
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2015.02.038

This work presents the rheological assessment of poly(methyl methacrylate) (PMMA) polymers synthesized in a dedicated pilot-scale plant. This material is to be used for the construction of scaffolds via Rapid Prototyping (RP).
The polymers were prepared to match the physical and biological properties required for medical applications. Differential Scanning Calorimetry (DSC) and Size Exclusion Chromatography (SEC) measurements verified that the synthesized polymers were atactic, amorphous and linear in chains. Rheological properties such as viscosity, storage and loss modulus, beyond the loss factor, and creep and recovery were measured in a plate–plate sensor within the viscoelastic linear region. The results showed the relevant influence of the molecular weight on the viscosity and elasticity of the material, and how, as the molecular weight increases, the viscoelastic properties are getting closer to those of human bone. This article demonstrates that by using the implemented methodology it is possible to synthesize a polymer, with properties comparable to commercially-available PMMA.
•A methodology of synthesis of PMMA polymers in a pilot-scale plant is presented.•We used an alternative combination of reagents to reduce the toxicity of the material.•Physico-chemical characterization exhibited the amorphous and linear structure of PMMA.•We estimated the K proportionality between the viscosity and the molecular weight.•The influence of the molecular weight on the viscoelastic properties is presented.