Prevalence of Antimicrobial Resistance and Clonal Relationship in ESBL/AmpC-Producing Proteus mirabilis Isolated from Meat Products and Community-Acquired Urinary Tract Infection (UTI-CA) in Southern Brazil

• Published in: Antibiotics (Basel) Vol. 12; no. 2; p. 370
• Main Authors: Sanches, Matheus Silva, Silva, Luana Carvalho, Silva, Caroline Rodrigues da, Montini, Victor Hugo, Oliva, Bruno Henrique Dias de, Guidone, Gustavo Henrique Migliorini, Nogueira, Mara Corrêa Lelles, Menck-Costa, Maísa Fabiana, Kobayashi, Renata Katsuko Takayama, Vespero, Eliana Carolina, Rocha, Sergio Paulo Dejato
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10-02-2023; MDPI
• Subjects: Animals; Antimicrobial agents; Antimicrobial resistance; Beef; bla CMY-2; bla CTX-M-2; bla CTX-M-65; Chickens; Drug resistance; Genes; Infections; Meat; Meat products; Multidrug resistance; Plasmids; Pork; Poultry; Proteus mirabilis; Risk factors; Similarity; Urinary tract; Urinary tract infections; Urogenital system; Brazil; bla CTX-M-2; multidrug resistance; Proteus mirabilis; bla CMY-2; bla CTX-M-65
• ISSN: 2079-6382; 2079-6382
• DOI: 10.3390/antibiotics12020370

The present study aimed to evaluate the prevalence of antimicrobial resistance and clonal relationships in
isolated from chicken meat, beef, pork, and community-acquired urinary tract infections (UTI-CA). Chicken meat isolates showed the highest multidrug resistance (MDR), followed by those from pork and UTI-CA, whereas beef had relatively few MDR strains. All sources had strains that carried
, whereas
and
were only detected in chicken meat and UTI-CA isolates. This indicates that chicken meat should be considered an important risk factor for the spread of
carrying
and
. Furthermore, ESBL/AmpC producing strains were resistant to a greater number of antimicrobials and possessed more resistance genes than non-producing strains. In addition, the antimicrobial resistance genes
,
,
,
,
,
and
were also found. Molecular typing showed a genetic similarity between chicken meat and UTI-CA isolates, including some strains with 100% similarity, indicating that chicken can be a source of
causing UTI-CA. It was concluded that meat, especially chicken meat, can be an important source of dissemination of multidrug-resistant
in the community.