A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma

• Published in: International journal of oral science Vol. 3; no. 4; pp. 180 - 191
• Main Authors: Fan, Song, Tang, Qiong‐lan, Lin, Ying‐jin, Chen, Wei‐liang, Li, Jin‐song, Huang, Zhi‐quan, Yang, Zhao‐hui, Wang, You‐yuan, Zhang, Da‐ming, Wang, Hui‐jing, Dias‐Ribeiro, Eduardo, Cai, Qiang, Wang, Lei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-10-2011; Springer Nature B.V; Department of Oral and Maxillofacial Surgery,Sun Yet-Sen Memorial Hospital(Second Affiliated Hospital)of Sun Yat-Sen University,Guangzhou 510120,China%Department of Pathology,Sun Yet-Sen Memorial Hospital(Second Affiliated Hospital)of Sun Yat-Sen University,Guangzhou 510120,China%Department of Neurology,The First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China%Faculty of Dentistry,University Center of Joao Pessoa,Joao Pessoa 1602,Brazil%Department of Oral and Maxillofacial Surgery,Sun Yet-Sen Memorial HospitalSecond Affiliated Hospitalof Sun Yat-Sen University,Guangzhou 510120,China; Nature Publishing Group
• Subjects: Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - surgery; Dentistry; Humans; Lymph Nodes - pathology; Lymphatic Metastasis; Medicine; Mouth Floor - pathology; Mouth Neoplasms - pathology; Mouth Neoplasms - radiotherapy; Mouth Neoplasms - surgery; Neck - pathology; Neck Dissection; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Oral and Maxillofacial Surgery; Orthopedics; Radiotherapy, Adjuvant; Review; Surgical Orthopedics; 临床医生; 口腔; 审查; 淋巴结肿大; 病理组织学; 肿瘤细胞; 颈部; 鳞状细胞癌; oral squamous cell carcinoma; neck dissection; head and neck cancer; contralateral neck metastasis; lymph node metastasis
• ISSN: 1674-2818; 2049-3169
• DOI: 10.4248/IJOS11068

Oral squamous cell carcinoma （OSCC） has a high incidence of cervical micrometastases and sometimes metastasizes contralaterally because of the rich lymphatic intercommunications relative to submucosal plexus of oral cavity that freely communicate across the midline, and it can facilitate the spread of neoplastic cells to any area of the neck consequently. Clinical and histopathologic factors continue to provide predictive information to contralateral neck metastases （CLNM） in OSCC, which determine prophylactic and adjuvant treatments for an individual patient. This review describes the predictive value of clinical-histopathologic factors, which relate to primary tumor and cervical lymph nodes, and surgical dissection and adjuvant treatments. In addition, the indications for elective contralateral neck dissection and adjuvant radiotherapy （aRT） and strategies for follow-up are offered, which is strongly focused by clinicians to prevent later CLNM and poor prognosis subsequently.