Current research trends of nanomedicines

• Published in: Acta pharmaceutica Sinica. B Vol. 13; no. 11; pp. 4391 - 4416
• Main Authors: Liu, Qiuyue, Zou, Jiahui, Chen, Zhongjian, He, Wei, Wu, Wei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-11-2023; Elsevier
• Subjects: Clinical translation; Drug delivery; In vivo fate; Nanocarriers; Nanomedicine; Nanoparticles; Protein corona; Review; Trigger-responsive; Nanoparticles; In vivo fate; Trigger-responsive; Clinical translation; Drug delivery; Nanocarriers; Nanomedicine; Protein corona
• ISSN: 2211-3835; 2211-3843
• DOI: 10.1016/j.apsb.2023.05.018

Owing to the inherent shortcomings of traditional therapeutic drugs in terms of inadequate therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received widespread attention with significantly improved efficacy and reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, and controlling various diseases and are attracting an unfathomable amount of input of research resources. Against the backdrop of an exponentially growing number of publications, it is imperative to help the audience get a panorama image of the research activities in the field of nanomedicines. Herein, this review elaborates on the development trends of nanomedicines, emerging nanocarriers, in vivo fate and safety of nanomedicines, and their extensive applications. Moreover, the potential challenges and the obstacles hindering the clinical translation of nanomedicines are also discussed. The elaboration on various aspects of the research trends of nanomedicines may help enlighten the readers and set the route for future endeavors.
This review elaborates on the development trends of nanomedicines, emerging nanocarriers, in vivo fate and safety of nanomedicines, and their extensive applications. [Display omitted]