Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review

1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and detection. 2. Developments have led to improvements in detection sensitivity, enhancements in specificity and increased capacity. 3. Emerging...

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Bibliographic Details
Published in:	Xenobiotica Vol. 31; no. 8-9; pp. 599 - 617
Main Authors:	Plumb, R. S., Dear, G. J., Mallett, D. N., Higton, D. M., Pleasance, S., Biddlecombe, R. A.
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 2001 Taylor & Francis
Subjects:	Animals Body Fluids - chemistry Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Humans Mass Spectrometry - instrumentation Mass Spectrometry - methods Pharmaceutical Preparations - analysis Robotics
Online Access:	Get full text
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Summary:	1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and detection. 2. Developments have led to improvements in detection sensitivity, enhancements in specificity and increased capacity. 3. Emerging technologies such as monolithic column chromatography and miniaturized chip-based systems are discussed.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0049-8254 1366-5928
DOI:	10.1080/00498250110060941