Aberrant activation of canonical Notch1 signaling in the mouse uterus decreases progesterone receptor by hypermethylation and leads to infertility

In mammalian reproduction, implantation is one of the most critical events. Failure of implantation and the subsequent decidualization contribute to more than 75% of pregnancy losses in women. Our laboratory has previously reported that inhibition of Notch signaling results in impaired decidualizati...

Full description

Saved in:

Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 8; pp. 2300 - 2305
Main Authors:	Su, Ren-Wei, Strug, Michael R., Jeong, Jae-Wook, Miele, Lucio, Fazleabas, Asgerally T.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 23-02-2016 National Acad Sciences
Subjects:	Animals Biological Sciences Disease Models, Animal DNA Methylation Epigenesis, Genetic Epigenetics Estradiol - metabolism Female Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein - deficiency Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism Infertility, Female - etiology Infertility, Female - genetics Infertility, Female - metabolism Mice Mice, Knockout Mice, Transgenic Pregnancy Progesterone Progesterone - metabolism Promoter Regions, Genetic Protein expression Protein Structure, Tertiary Receptor, Notch1 - chemistry Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Receptors, Progesterone - genetics Receptors, Progesterone - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Reproduction RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Up-Regulation Uterus - metabolism Uterus - pathology Pgr infertility Notch1 methylation mouse uterus
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!