Induction of cMrp/cMoat gene expression by cisplatin, 2- acetylaminofluorene, or cycloheximide in rat hepatocytes

The human multidrug-resistance-associated protein (MRP), a member of the adenosine triphosphate (ATP)-binding cassette transporter superfamily, is frequently overexpressed in tumor cells resistant to antineoplastic drugs. In the rat, two Mrp isoforms have been identified, Mrp and cMrp. cMrp, also ca...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 26; no. 4; pp. 980 - 985
Main Authors:	Kauffmann, H, Keppler, D, Kartenbeck, J, Schrenk, D
Format:	Journal Article
Language:	English
Published:	Hoboken, NJ Elsevier Inc 01-10-1997 Wiley
Subjects:	2-Acetylaminofluorene - pharmacology Animals Anion Transport Proteins ATP-Binding Cassette Transporters - genetics Biological and medical sciences Carrier Proteins - genetics Cells, Cultured Cisplatin - pharmacology Cycloheximide - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation - drug effects Humans Liver - cytology Liver - drug effects Liver - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Multidrug Resistance-Associated Proteins Rats Rats, Wistar Tumors Antineoplastic agent Cell culture Rat Rodentia Hepatic disease Hepatocellular carcinoma Malignant tumor Gene expression Carcinogenesis In vitro Cisplatin Cycloheximide Vertebrata Chemotherapy Mammalia Animal C-Onc gene Digestive diseases Fluorene derivatives Negative therapeutic reaction Protooncogene Platinum II Complexes
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