Efficient "green" encapsulation of a highly hydrophilic anticancer drug in metal-organic framework nanoparticles

Metal-organic frameworks (MOFs) are coordination polymers of interest for biomedical applications. Of particular importance, nanoparticles made of iron(III) trimesate (MIL-100, MIL standing for Material Institut Lavoisier) (nanoMOFs) can be conveniently synthesised under mild and green conditions. T...

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Bibliographic Details
Published in:	Journal of drug targeting Vol. 23; no. 7-8; pp. 759 - 767
Main Authors:	Rodriguez-Ruiz, Violeta, Maksimenko, Andrei, Anand, Resmi, Monti, Sandra, Agostoni, Valentina, Couvreur, Patrick, Lampropoulou, Maria, Yannakopoulou, Konstantina, Gref, Ruxandra
Format:	Journal Article
Language:	English
Published:	England Informa Healthcare 14-09-2015
Subjects:	"green" synthesis Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - chemistry Antimetabolites, Antineoplastic - pharmacology Cell Line, Tumor Crystallization Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - chemistry Deoxycytidine - pharmacology Drug Liberation Drug Stability Drug Storage Engineering Sciences Ferric Compounds - chemistry Gemcitabin Humans Hydrophobic and Hydrophilic Interactions Life Sciences Metal Nanoparticles metal-organic frameworks Micro and nanotechnologies Microelectronics MOF nanoparticle nucleoside analog Organometallic Compounds - chemistry Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Pharmaceutical sciences Phosphates - chemistry Polymers - chemistry Prodrugs - administration & dosage Prodrugs - chemistry prostate cancer Gemcitabin prostate cancer MOF nanoparticle metal–organic frameworks nucleoside analog “green” synthesis
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