Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non‐canonical tumour‐associated mucin 1‐8 peptide

Summary Designing peptide‐based vaccines for therapeutic applications in cancer immunotherapy requires detailed knowledge of the interactions between the antigenic peptide and major histocompatibility complex (MHC) in addition to that between the peptide–MHC complex and the T‐cell receptor. Past eff...

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Bibliographic Details
Published in:	Immunology Vol. 119; no. 3; pp. 306 - 316
Main Authors:	Lazoura, Eliada, Lodding, Jodie, Farrugia, William, Ramsland, Paul A., Stevens, James, Wilson, Ian A., Pietersz, Geoffrey A., Apostolopoulos, Vasso
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-11-2006 Wiley Subscription Services, Inc Blackwell Science Inc
Subjects:	anchor modifications Animals Antigens, Neoplasm - immunology Cancer Vaccines - chemistry Cancer Vaccines - immunology Cell Line Crystallography, X-Ray Drosophila melanogaster H-2 Antigens - metabolism Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism H‐2Kb Immunity, Cellular Mice Mice, Inbred C57BL Mice, Transgenic Models, Molecular mucin 1 mucin 1‐8 Mucin-1 - genetics Mucin-1 - immunology Mucin-1 - metabolism Mutation non‐canonical peptide Original Peptide Fragments - genetics Peptide Fragments - immunology Peptide Fragments - metabolism Protein Binding Structure-Activity Relationship T-Lymphocyte Subsets - immunology vaccine design
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