Normative data for TM electrocochleography measures

• Published in: Journal of otology (Beijing) Vol. 12; no. 2; pp. 68 - 73
• Main Authors: Grasel, Signe Schuster, Beck, Roberto Miquelino de Oliveira, Loureiro, Ricardo Silva Chiabai, Rossi, Amanda Costa, de Almeida, Edigar Rezende, Ferraro, John
• Format: Journal Article
• Language: English
• Published: Elsevier (Singapore) Pte Ltd 01-06-2017; University of Sao Paulo School of Medicine, Dr. Eneas de Carvalho Aguiar, 255, sala 6173, Cerqueira César, Sao Paulo, SP CEP 05403-000, Brazil%University of Kansas Medical Center, Kansas City, KS 66160, USA; Chinese PLA General Hospital; Elsevier
• Subjects: disease; Dizziness; Electrocochleography; Hearing; Meniere; Ménière disease; Tinnitus; Ménière disease; Dizziness; Hearing; Tinnitus; Electrocochleography
• ISSN: 1672-2930
• DOI: 10.1016/j.joto.2017.04.005

Objective: Establish normative data for tympanic electrocochleography (TM ECochG) parameters in normal hearing adults without Meniere's disease's (MD) symptoms. Describe TM ECochG variables that help to distinguish normal from MD ears.Material and methods: We enrolled 100 subjects (N ? 200 ears), 59 females, aged between 19 and 71 years from 09/2010 to 04/2014. Inclusion criteria: normal otomicroscopy, hearing thresholds 25 dB nHL from 250 to 4000 Hz, normal tympanogram, no symptoms of MD according to the AAO-HNS 1995 criteria and Gibson's score <7. We excluded subjects with dizziness, aural fullness or other symptoms of endolymphatic hydrops. The following parameters were analyzed: SP/AP amplitude ratio, SP/AP area ratio and the difference between AP latency with rarefaction and condensation stimuli.Results: There was no significant difference between right and left ears (Intraclass correlation coefficient < 0.6). SP/AP amplitude ratio varied between 0.084 and 0.356 and SP/AP area ratio between 0.837 and 1.671 (percentiles 5 and 95). The AP latency difference to rarefaction and condensation clicks was between 0.0 and 0.333 ms.Conclusion: Normative data for TM ECochG parameters were established in 100 normal hearing subjects without MD. These data can be used to distinguish normal from pathological findings and in follow-up of MD patients.