Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects

Background: The c-erbB family of receptor tyrosine kinases act in a combinatorial fashion to regulate cell behavior. Disturbances in this system have been associated with neoplastic and inflammatory diseases. Objectives: Although expression of the epidermal growth factor receptor (EGFR; c-erbB1) is...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 109; no. 1; pp. 75 - 81
Main Authors:	Polosa, Riccardo, Puddicombe, Sarah M., Krishna, M.Thirumala, Tuck, Angela B., Howarth, Peter H., Holgate, Stephen T., Davies, Donna E.
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01-01-2002 Elsevier Elsevier Limited
Subjects:	Adult Allergic diseases Asthma Asthma - metabolism Biological and medical sciences Bronchi - chemistry bronchial epithelium c-ErbB protein Cloning Cystic fibrosis Epidermal growth factor Epidermal Growth Factor - analysis Epithelium - chemistry erbB receptor ErbB Receptors - analysis Female Heparin-binding EGF-like Growth Factor Humans Immunohistochemistry Immunopathology Intercellular Signaling Peptides and Proteins Ligands Male Medical sciences phosphorylation Polyclonal antibodies Receptor, ErbB-2 - analysis Receptor, ErbB-3 - analysis Respiratory and ent allergic diseases Studies Transforming Growth Factor alpha - analysis transforming growth factor α wound repair wound repair EGF HB-EGF erbB receptor EGFR Asthma HER TGF-α transforming growth factor α SFM epidermal growth factor bronchial epithelium phosphorylation Human Immunohistochemistry Immunopathology Allergy Phosphorylation Respiratory disease Enzyme Pathogenesis Transferases Epidermal growth factor Transforming growth factor α Obstructive pulmonary disease Protein-tyrosine kinase Biological receptor
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