Preparation of designed poly(d,l-lactide)/nanosized hydroxyapatite composite structures by stereolithography
The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key properties of the biomaterials used to prepare such scaffolds include biodegradability, biocompatibility and a well-defined three-dimensional 3-...
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Published in: | Acta biomaterialia Vol. 9; no. 4; pp. 5989 - 5996 |
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01-04-2013
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Abstract | The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key properties of the biomaterials used to prepare such scaffolds include biodegradability, biocompatibility and a well-defined three-dimensional 3-Dpore network structure. In this study a poly(d,l-lactide)/nanosized hydroxyapatite (PDLLA/nano-Hap) composite resin was prepared and used to fabricate composite films and computer designed porous scaffolds by micro-stereolithography, mixing varying quantities of nano-Hap powder and a liquid photoinitiator into a photo-crosslinkable PDLLA-diacrylate resin. The influence of nano-Hap on the rheological and photochemical properties of the resins was investigated, the materials being characterized with respect to their mechanical, thermal and morphological properties after post-preparation curing. In the cured composites stiffness was observed to increase with increasing concentration of nanoparticles. A computer designed construct with a pore network based on the Schwarz architecture was fabricated by stereolithography using PDLLA/nano-Hap composite resins. |
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AbstractList | The key properties of the biomaterials used to prepare scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering include biodegradability, biocompatibility and a well-defined 3-D pore network structure. A poly(D,L-lactide)/nanosized hydroxyapatite (PDLLA/nano-HAp) composite resin was prepared and used to fabricate composite films and computer designed porous scaffolds by micro-stereolithography, mixing varying quantities of nano-HAp powder and a liquid photoinitiator into a photo-crosslinkable PDLLA-diacrylate resin. The influence of nano-HAp on the rheological and photochemical properties of the resins was studied. The materials were characterised with respect to their mechanical, thermal and morphological properties after post-preparation curing. In the cured composites, stiffness increased with increasing concentration of nanoparticles. A computer designed construct with a pore network based on the Schwarz architecture was fabricated by stereolithography using PDLLA/nano-HAp composite resins. The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key properties of the biomaterials used to prepare such scaffolds include biodegradability, biocompatibility and a well-defined three-dimensional 3-Dpore network structure. In this study a poly(D,L-lactide)/nanosized hydroxyapatite (PDLLA/nano-Hap) composite resin was prepared and used to fabricate composite films and computer designed porous scaffolds by micro-stereolithography, mixing varying quantities of nano-Hap powder and a liquid photoinitiator into a photo-crosslinkable PDLLA-diacrylate resin. The influence of nano-Hap on the rheological and photochemical properties of the resins was investigated, the materials being characterized with respect to their mechanical, thermal and morphological properties after post-preparation curing. In the cured composites stiffness was observed to increase with increasing concentration of nanoparticles. A computer designed construct with a pore network based on the Schwarz architecture was fabricated by stereolithography using PDLLA/nano-Hap composite resins. |
Author | Grijpma, D.W. Ambrosio, L. Ronca, A. |
Author_xml | – sequence: 1 givenname: A. surname: Ronca fullname: Ronca, A. email: alfredo.ronca@unina.it, alfredoronca82@hotmail.it organization: Institute of Composite and Biomedical Materials, National Research Council of Italy, Piazzale Tecchio 80, 80125 Naples, Italy – sequence: 2 givenname: L. surname: Ambrosio fullname: Ambrosio, L. organization: Institute of Composite and Biomedical Materials, National Research Council of Italy, Piazzale Tecchio 80, 80125 Naples, Italy – sequence: 3 givenname: D.W. surname: Grijpma fullname: Grijpma, D.W. organization: MIRA Institute for Biomedical Technology and Technical Medicine, Department of Polymer Chemistry and Biomaterials, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23232210$$D View this record in MEDLINE/PubMed |
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Keywords | Biodegradable networks CAD designed scaffold Nano-composites Bone tissue engineering Stereolithography |
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Snippet | The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key... The key properties of the biomaterials used to prepare scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering... |
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SubjectTerms | biocompatibility biocompatible materials Biocompatible Materials - chemical synthesis biodegradability Biodegradable networks Bone tissue engineering CAD designed scaffold Computer-Aided Design Durapatite - chemistry Equipment Design Equipment Failure Analysis Hydroxyapatite Materials Testing mixing Nano-composites Nanocomposites Nanomaterials nanoparticles Nanostructure Nanostructures - chemistry Nanostructures - ultrastructure Networks Particle Size Photography - methods Polyesters - chemistry Polymers Resins Resins, Synthetic - chemical synthesis Scaffolds Stereolithography Surface Properties tissue engineering Tissue Engineering - instrumentation Tissue Scaffolds |
Title | Preparation of designed poly(d,l-lactide)/nanosized hydroxyapatite composite structures by stereolithography |
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