Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney

The aim of this study was to investigate the effects of flavone luteolin against cisplatin (CP)-induced kidney injury in mice. Luteolin at doses of 10mg/kg was administered intraperitoneally (ip) once daily for 3 days following single CP (10 or 20mg/kg) ip injection. Mice were sacrificed 24h after t...

Full description

Saved in:

Bibliographic Details
Published in:	Toxicology (Amsterdam) Vol. 310; pp. 115 - 123
Main Authors:	Domitrović, Robert, Cvijanović, Olga, Pugel, Ester Pernjak, Zagorac, Gordana Blagojević, Mahmutefendić, Hana, Škoda, Marko
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 09-08-2013
Subjects:	Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - toxicity Apoptosis Apoptosis - drug effects Biomarkers - blood blood serum Blotting, Western caspase-3 cisplatin Cisplatin - pharmacokinetics Cisplatin - toxicity Cisplatin nephrotoxicity creatinine cytochrome P-450 Dose-Response Relationship, Drug Drug Administration Schedule Emergency glutathione Immunohistochemistry Inflammation Kidney - drug effects Kidney - immunology Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - prevention & control Kidney Function Tests kidneys Luteolin Luteolin - administration & dosage Luteolin - pharmacology Luteolin - therapeutic use Male Mice Mice, Inbred BALB C nephroprotective effect nephrotoxicity Oxidative Stress - drug effects Oxidative/nitrosative stress platinum Platinum - metabolism prostaglandin synthase toxicology transcription factor NF-kappa B tumor necrosis factor-alpha urea nitrogen Inflammation Luteolin Cisplatin nephrotoxicity Oxidative/nitrosative stress Apoptosis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!