Treatment options for advanced keratoconus: A review

• Published in: Survey of ophthalmology Vol. 60; no. 5; pp. 459 - 480
• Main Authors: Parker, Jack S., MD, van Dijk, Korine, BSc, Melles, Gerrit R.J., MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-09-2015
• Subjects: advanced keratoconus; Bowman layer transplantation; Corneal Transplantation; Cross-Linking Reagents; DALK; Humans; intracorneal ring segments; Keratoconus - drug therapy; Keratoconus - surgery; Keratoconus - therapy; Keratoplasty, Penetrating; Ophthalmology; Photosensitizing Agents; Prosthesis Implantation; review; UV crosslinking; advanced keratoconus; DALK; UV crosslinking; Bowman layer transplantation; review; intracorneal ring segments
• ISSN: 0039-6257; 1879-3304
• DOI: 10.1016/j.survophthal.2015.02.004

Abstract Traditionally, the mainstay of treatment for advanced keratoconus (KC) has been either penetrating or deep anterior lamellar keratoplasty (PK or DALK, respectively). The success of both operations, however, has been somewhat tempered by potential difficulties and complications, both intraoperatively and postoperatively. These include suture and wound-healing problems, progression of disease in the recipient rim, allograft reaction, and persistent irregular astigmatism. Taken together, these have been the inspiration for an ongoing search for less troublesome therapeutic alternatives. These include ultraviolet crosslinking and intracorneal ring segments, both of which were originally constrained in their indication exclusively to eyes with mild to moderate disease. More recently, Bowman layer transplantation has been introduced for reversing corneal ectasia in eyes with advanced KC, re-enabling comfortable contact lens wear and permitting PK and DALK to be postponed or avoided entirely. We offer a summary of the current and emerging treatment options for advanced KC, aiming to provide the corneal specialist useful information in selecting the optimal therapy for individual patients.