Altered gene expression in kidneys of mice with 2,8-dihydroxyadenine nephrolithiasis

Altered gene expression in kidneys of mice with 2,8-dihydroxyadenine nephrolithiasis. We have developed a knockout mouse model for adenine phosphoribosyltransferase (APRT) deficiency, a condition that often leads to 2,8-dihydroxyadenine (DHA) nephrolithiasis in humans. Aprt knockout male mice develo...

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Bibliographic Details
Published in:	Kidney international Vol. 58; no. 2; pp. 528 - 536
Main Authors:	Wang, Li, Raikwar, Nandita, Deng, Li, Yang, Min, Liang, Li, Shao, Changshun, Evan, Andrew P., Stambrook, Peter J., Sahota, Amrik, Tischfield, Jay A.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-08-2000 Nature Publishing Elsevier Limited
Subjects:	Adenine - analogs & derivatives Adenine - metabolism Adenine Phosphoribosyltransferase - deficiency Adenine Phosphoribosyltransferase - genetics Age Factors Animals Biological and medical sciences Complex syndromes crystalluria Disease Models, Animal DNA Primers DNA, Complementary Female Gene Expression - physiology gene knockout mice hematuria Kidney - physiology Kidney Calculi - enzymology Kidney Calculi - physiopathology Male Medical genetics Medical sciences Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout renal gene RNA, Messenger - analysis Sex Characteristics urinary tract infection hematuria adenine phosphoribosyltransferase deficiency gene knockout mice crystalluria urinary tract infection renal gene Kidney disease Animal model Urinary system disease Rodentia Sex Gene expression Kidney Urinary stone Polymerase chain reaction Vertebrata Mammalia Mouse Animal Lithiasis Age Comparative study
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