Risk Scoring System for Prognosis Estimation of Multivessel Disease Among Patients with ST-Segment Elevation Myocardial Infarction
Multivessel disease (MVD) is an independent risk factor for poor prognosis in acute myocardial infarction patients. Although several global risk scoring systems (RSS) are in use in clinical practice, there is no dedicated RSS for MVD in ST-segment elevation myocardial infarction (STEMI). The primary...
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Published in: | International Heart Journal Vol. 60; no. 3; pp. 708 - 714 |
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Abstract | Multivessel disease (MVD) is an independent risk factor for poor prognosis in acute myocardial infarction patients. Although several global risk scoring systems (RSS) are in use in clinical practice, there is no dedicated RSS for MVD in ST-segment elevation myocardial infarction (STEMI). The primary objective of this study is to develop a novel RSS to estimate the prognosis of patients with MVD in STEMI.We used the Korean Acute Myocardial Infarction Registry (KAMIR) to identify 2,030 STEMI patients with MVD who underwent appropriate percutaneous coronary intervention (PCI). Their data were analyzed to develop a new RSS. The prognostic power of this RSS was validated with 2,556 STEMI patients with MVD in the Korean Working Group on Myocardial Infarction Registry (KORMI).Six prognostic factors related to all-cause death in STEMI patients with MVD were age, serum creatinine, Killip Class, lower body weight, decrease in left ventricular ejection fraction, and history of cerebrovascular disease. The RSS for all-cause death was constructed using these risk factors and their statistical weight. The RSS had appropriate performance (c-index: 0.72) in the KORMI validation cohort.We developed a novel RSS that estimates all-cause death in the year following discharge for patients with MVD in STEMI appropriately treated by PCI. This novel RSS was transformed into a simple linear risk score to yield a simplified estimate prognosis of MVD among STEMI patients. |
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AbstractList | Multivessel disease (MVD) is an independent risk factor for poor prognosis in acute myocardial infarction patients. Although several global risk scoring systems (RSS) are in use in clinical practice, there is no dedicated RSS for MVD in ST-segment elevation myocardial infarction (STEMI). The primary objective of this study is to develop a novel RSS to estimate the prognosis of patients with MVD in STEMI.We used the Korean Acute Myocardial Infarction Registry (KAMIR) to identify 2,030 STEMI patients with MVD who underwent appropriate percutaneous coronary intervention (PCI). Their data were analyzed to develop a new RSS. The prognostic power of this RSS was validated with 2,556 STEMI patients with MVD in the Korean Working Group on Myocardial Infarction Registry (KORMI).Six prognostic factors related to all-cause death in STEMI patients with MVD were age, serum creatinine, Killip Class, lower body weight, decrease in left ventricular ejection fraction, and history of cerebrovascular disease. The RSS for all-cause death was constructed using these risk factors and their statistical weight. The RSS had appropriate performance (c-index: 0.72) in the KORMI validation cohort.We developed a novel RSS that estimates all-cause death in the year following discharge for patients with MVD in STEMI appropriately treated by PCI. This novel RSS was transformed into a simple linear risk score to yield a simplified estimate prognosis of MVD among STEMI patients. |
Author | and other Korea Acute Myocardial Infarction Registry Investigators Jeong, Myung Ho Ryu, Kwang Sun Cho, Myeong-Chan Bae, Jang-Whan Ryu, Keun-Ho |
Author_xml | – sequence: 1 fullname: Ryu, Kwang Sun organization: Korea Centers for Disease Control and Prevention – sequence: 2 fullname: Bae, Jang-Whan organization: Department of Internal Medicine, College of Medicine, Chungbuk National University – sequence: 3 fullname: Jeong, Myung Ho organization: The Heart Center of Chonnam National University – sequence: 4 fullname: Cho, Myeong-Chan organization: Department of Internal Medicine, College of Medicine, Chungbuk National University – sequence: 5 fullname: Ryu, Keun-Ho organization: Database/Bioinformatics Lab, School of Electrical & Computer Engineering, Chungbuk National University – sequence: 6 fullname: and other Korea Acute Myocardial Infarction Registry Investigators |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31105140$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1159_000515759 crossref_primary_10_1155_2022_1357737 crossref_primary_10_3390_app10093046 crossref_primary_10_1016_j_ihj_2021_11_184 crossref_primary_10_1371_journal_pone_0225991 crossref_primary_10_3390_app10010421 crossref_primary_10_3390_app10217741 crossref_primary_10_1253_circj_CJ_20_0133 crossref_primary_10_2147_IJGM_S457236 |
Cites_doi | 10.1536/ihj.16-170 10.1001/archinte.158.6.601 10.1016/j.ijcard.2016.06.100 10.1001/archinte.163.19.2345 10.1002/sim.6370 10.4070/kcj.2015.45.1.22 10.1536/ihj.15-402 10.4070/kcj.2013.43.2.100 10.1016/j.ahj.2015.10.024 10.1097/MD.0000000000003882 10.1016/j.jjcc.2009.10.004 10.1536/ihj.16-286 10.1016/j.ahj.2013.03.023 10.1067/mhj.2003.6 10.1016/j.amjcard.2010.11.018 10.1016/j.amjmed.2012.01.018 10.1111/j.1440-1681.2010.05363.x 10.1016/j.amjcard.2006.11.038 10.1016/j.amjcard.2006.06.010 10.1016/j.ahj.2006.10.004 10.1016/j.ahj.2005.03.024 10.1253/circj.CJ-14-0808 10.1001/jama.291.22.2727 10.1016/S0019-4832(12)60084-4 |
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Snippet | Multivessel disease (MVD) is an independent risk factor for poor prognosis in acute myocardial infarction patients. Although several global risk scoring... |
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SubjectTerms | Acute Disease Aged Body Mass Index Body weight Cause of Death Cerebrovascular diseases Coronary Angiography - methods Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary Artery Disease - mortality Creatinine Death Electrocardiography Female Heart Heart attacks Humans Male Medical prognosis Middle Aged Myocardial infarction Myocardial Infarction - epidemiology Myocardial Infarction - mortality Myocardial Infarction - physiopathology Myocardial Infarction - surgery Obesity paradox Percutaneous coronary intervention Percutaneous Coronary Intervention - methods Prognosis Republic of Korea - epidemiology Risk Factors ST Elevation Myocardial Infarction - physiopathology Stents Stroke Volume - physiology Ventricle Ventricular Function, Left - physiology |
Title | Risk Scoring System for Prognosis Estimation of Multivessel Disease Among Patients with ST-Segment Elevation Myocardial Infarction |
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