Relevant Issues in the Monitoring and the Toxicology of Antidepressants

This review provides specific information concerning the interpretation and usefulness of antidepressant drug monitoring. Fifteen antidepressants (ADs) were selected based on their importance in the 7 major markets (Japan, USA, France, United Kingdom, Italy, Spain, Germany) according to the Cognos P...

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Published in:	Critical reviews in clinical laboratory sciences Vol. 45; no. 1; pp. 25 - 89
Main Authors:	Wille, Sarah M. R., Cooreman, Sarah G., Neels, Hugo M., Lambert, Willy E. E.
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 2008 Taylor & Francis Taylor & Francis Ltd
Subjects:	analytical methods Antidepressants Antidepressive Agents - classification Antidepressive Agents - toxicity Biochemistry Centre of Psychiatric Neurosciences CHUV Clinical Trials as Topic Department of Biochemistry and Clinical Psychopharmacology Depression Depression - drug therapy Depression - etiology Depression - physiopathology Drug Interactions Drug Monitoring Drug Therapy, Combination Global Health Humans Medical research monoamine oxidase inhibitors noradrenergic and specific serotonergic antidepressants Pharmacology Pierre Baumann Prilly-Lausanne selective noradrenaline reuptake inhibitors selective serotonin reuptake enhancer selective serotonin reuptake inhibitors serotonin and noradrenaline reuptake inhibitors serotonin-antagonist and reuptake inhibitors St. John's Wort Switzerland therapeutic drug monitoring Toxicology tricyclic antidepressants Italy United Kingdom > UK France United States > US Japan Spain
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Abstract	This review provides specific information concerning the interpretation and usefulness of antidepressant drug monitoring. Fifteen antidepressants (ADs) were selected based on their importance in the 7 major markets (Japan, USA, France, United Kingdom, Italy, Spain, Germany) according to the Cognos Plus Study #11. Literature data were reviewed concerning monitoring of the tricyclic ADs amitriptyline, clomipramine, imipramine, and new generation antidepressants such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine, mianserin, mirtazapine, bupropion, and milnacipran. In addition, St.-John's Wort was added as this natural antidepressant is very popular in Europe. The objectives of therapeutic drug monitoring (TDM) for old and new generation ADs differs, as older ADs have narrow therapeutic windows with higher risks of severe drug interactions, while the new ADs have a wide therapeutic range, but an unclear plasma concentration-effect relationship. Therefore, the purpose of TDM for new-generation ADs leads more to the monitoring of patient compliance and special patient groups such as the elderly, patients with liver and kidney impairment, patients with poor metabolism by CYP 450 and comedication with inhibitors and inducers of those enzymes.
AbstractList	This review provides specific information concerning the interpretation and usefulness of antidepressant drug monitoring. Fifteen antidepressants (ADs) were selected based on their importance in the 7 major markets (Japan, USA, France, United Kingdom, Italy, Spain, Germany) according to the Cognos Plus Study #11. Literature data were reviewed concerning monitoring of the tricyclic ADs amitriptyline, clomipramine, imipramine, and new generation antidepressants such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine, mianserin, mirtazapine, bupropion, and milnacipran. In addition, St.-John's Wort was added as this natural antidepressant is very popular in Europe. The objectives of therapeutic drug monitoring (TDM) for old and new generation ADs differs, as older ADs have narrow therapeutic windows with higher risks of severe drug interactions, while the new ADs have a wide therapeutic range, but an unclear plasma concentration-effect relationship. Therefore, the purpose of TDM for new-generation ADs leads more to the monitoring of patient compliance and special patient groups such as the elderly, patients with liver and kidney impairment, patients with poor metabolism by CYP 450 and comedication with inhibitors and inducers of those enzymes. This review provides specific information concerning the interpretation and usefulness of antidepressant drug monitoring. Fifteen antidepressants (ADs) were selected based on their importance in the 7 major markets (Japan, USA, France, United Kingdom, Italy, Spain, Germany) according to the Cognos Plus Study #11. Literature data were reviewed concerning monitoring of the tricyclic ADs amitriptyline, clomipramine, imipramine, and new generation antidepressants such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine, mianserin, mirtazapine, bupropion, and milnacipran. In addition, St.-John's Wort was added as this natural antidepressant is very popular in Europe. The objectives of therapeutic drug monitoring (TDM) for old and new generation ADs differs, as older ADs have narrow therapeutic windows with higher risks of severe drug interactions, while the new ADs have a wide therapeutic range, but an unclear plasma concentration-effect relationship. Therefore, the purpose of TDM for new-generation ADs leads more to the monitoring of patient compliance and special patient groups such as the elderly, patients with liver and kidney impairment, patients with poor metabolism by CYP 450 and comedication with inhibitors and inducers of those enzymes. [PUBLICATION ABSTRACT]
Author	Wille, Sarah M. R. Neels, Hugo M. Lambert, Willy E. E. Cooreman, Sarah G.
Author_xml	– sequence: 1 givenname: Sarah M. R. surname: Wille fullname: Wille, Sarah M. R. organization: Laboratory of Toxicology, Ghent University, Gent, Belgium – sequence: 2 givenname: Sarah G. surname: Cooreman fullname: Cooreman, Sarah G. organization: Laboratory of Toxicology, Ghent University, Gent, Belgium – sequence: 3 givenname: Hugo M. surname: Neels fullname: Neels, Hugo M. organization: Laboratory of Toxicology, Ghent University, Gent, Belgium – sequence: 4 givenname: Willy E. E. surname: Lambert fullname: Lambert, Willy E. E. organization: Laboratory of Toxicology, Ghent University, Gent, Belgium
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18293180$$D View this record in MEDLINE/PubMed
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Snippet	This review provides specific information concerning the interpretation and usefulness of antidepressant drug monitoring. Fifteen antidepressants (ADs) were...
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SubjectTerms	analytical methods Antidepressants Antidepressive Agents - classification Antidepressive Agents - toxicity Biochemistry Centre of Psychiatric Neurosciences CHUV Clinical Trials as Topic Department of Biochemistry and Clinical Psychopharmacology Depression Depression - drug therapy Depression - etiology Depression - physiopathology Drug Interactions Drug Monitoring Drug Therapy, Combination Global Health Humans Medical research monoamine oxidase inhibitors noradrenergic and specific serotonergic antidepressants Pharmacology Pierre Baumann Prilly-Lausanne selective noradrenaline reuptake inhibitors selective serotonin reuptake enhancer selective serotonin reuptake inhibitors serotonin and noradrenaline reuptake inhibitors serotonin-antagonist and reuptake inhibitors St. John's Wort Switzerland therapeutic drug monitoring Toxicology tricyclic antidepressants
Title	Relevant Issues in the Monitoring and the Toxicology of Antidepressants
URI	https://www.tandfonline.com/doi/abs/10.1080/10408360701713112 https://www.ncbi.nlm.nih.gov/pubmed/18293180 https://www.proquest.com/docview/204145782
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