Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells

Through direct interaction with the voltage-dependent anion channel (VDAC), proapoptotic members of the Bcl-2 family such as Bax and Bak induce apoptogenic cytochrome c release in isolated mitochondria, whereas BH3-only proteins such as Bid and Bik do not directly target the VDAC to induce cytochrom...

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 152; no. 2; pp. 237 - 250
Main Authors:	Shimizu, Shigeomi, Matsuoka, Yosuke, Shinohara, Yasuo, Yoneda, Yoshihiro, Tsujimoto, Yoshihide
Format:	Journal Article
Language:	English
Published:	United States Rockefeller University Press 22-01-2001 The Rockefeller University Press
Subjects:	Amino Acid Sequence Animals Antibodies Antibodies - pharmacology Antibodies, Monoclonal - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins bcl-2 Homologous Antagonist-Killer Protein bcl-2-Associated X Protein BH3 Interacting Domain Death Agonist Protein Carrier Proteins - metabolism Cell death Cell membranes Cells Chromium Cytochrome c Group - metabolism Cytochromes Erythrocytes - physiology Etoposide - pharmacology Genes HeLa Cells Humans Ion Channels - physiology Liposomes Mammals Membrane Proteins - metabolism Mitochondria Mitochondria - physiology Mitochondria, Liver - physiology Molecular Sequence Data Original Paclitaxel - pharmacology Porins - chemistry Porins - physiology Protein Conformation Proteins Proteins - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Inbred Strains Recombinant Proteins - metabolism Staurosporine - pharmacology Transfection Voltage-Dependent Anion Channels
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